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Case report of Ureaplasma urealyticum meningitis in a patient with thymoma and hypogammaglobulinaemia.
Zhang, Ting; Li, Haiyan; Hou, Shuping; Yu, Huanxin; Yue, Wei.
Afiliación
  • Zhang T; Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.
  • Li H; Department of Neurology, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China.
  • Hou S; Department of Otolaryngology, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China.
  • Yu H; Department of Dermatology, Tianjin Medical University General Hospital, Tianjin, China.
  • Yue W; Department of Otolaryngology, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China.
BMC Infect Dis ; 21(1): 1142, 2021 Nov 08.
Article en En | MEDLINE | ID: mdl-34749670
BACKGROUND: Ureaplasma urealyticum (UU) is found among the normal vaginal flora in a considerable proportion of asymptomatic women; however, adult central nervous system (CNS) infection of UU is extremely rare. Good's syndrome (GS) is an adult-onset immunodeficiency characterized by thymoma, hypogammaglobulinaemia, low or absent B­cells, and an inverted CD4+/CD8+ T­cell ratio. Patients with GS usually have severe or recurrent infections. CASE PRESENTATION: We describe the case report of a 49-year-old woman who developed UU meningitis. Initial routine anti-viral and anti-bacterial therapy showed no improvement in the patient's condition. Next-generation sequencing (NGS) of cerebrospinal fluid (CSF) identified the UU DNA sequence. Accordingly, a diagnosis of UU meningitis was made, and minocycline therapy was initiated. The patient responded favourably, with no signs of disease at subsequent follow-up. According to the severity and rarity of the case, secondary immunodeficiency was suspected. Flow cytometry found hypogammaglobulinaemia. Combined with the previous history of thymoma, the patient was diagnosed with immune deficiency disease of GS. CONCLUSIONS: This case may be the first adult case report in the literature describing UU meningitis in a patient with GS. The diagnosis of GS should be considered in patients presenting with unexplained antibody deficiency and thymoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Timoma / Neoplasias del Timo / Agammaglobulinemia / Meningitis Tipo de estudio: Prognostic_studies Límite: Female / Humans / Middle aged Idioma: En Revista: BMC Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Timoma / Neoplasias del Timo / Agammaglobulinemia / Meningitis Tipo de estudio: Prognostic_studies Límite: Female / Humans / Middle aged Idioma: En Revista: BMC Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido