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A new uPAR-targeting fluorescent probe for optical guided intracranial surgery in resection of a meningioma-a case report.
Skjøth-Rasmussen, Jane; Azam, Aleena; Larsen, Carl Christian; Scheie, David; Juhl, Karina; Kjaer, Andreas.
Afiliación
  • Skjøth-Rasmussen J; Department of Neurosurgery, Neuroscience Center, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. jane@skjoeth-rasmussen.dk.
  • Azam A; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark.
  • Larsen CC; Department of Neurosurgery, Neuroscience Center, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Scheie D; Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
  • Juhl K; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark.
  • Kjaer A; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark.
Acta Neurochir (Wien) ; 164(1): 267-271, 2022 01.
Article en En | MEDLINE | ID: mdl-34748074
Meningiomas are benign lesion although anot insignificant number experiences recurrences despite Simpson grade 1 removal. FG001 is a compound with a fluorophore (ICG) that binds to a urokinase-type plasminogen activator receptor (uPAR) and is currently investigated at our institution in a first-in-human trial. The patient presented with a plausible malignant glioma but proved to be a grade 1 meningioma. FG001 could delineated the tumor not only on the surface but supplementary in the cavity to remove safely the dural attachment. We present FG001 as a new promising tool for improved surgical radicality beyond the intended indication, provided that a prospective validation in a consecutive meningioma cohort demonstrates similar results.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glioma / Neoplasias Meníngeas / Meningioma Límite: Child / Humans Idioma: En Revista: Acta Neurochir (Wien) Año: 2022 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Austria
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glioma / Neoplasias Meníngeas / Meningioma Límite: Child / Humans Idioma: En Revista: Acta Neurochir (Wien) Año: 2022 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Austria