Inhibition versus activation of canonical Wnt-signaling, to promote chondrogenic differentiation of Mesenchymal Stem Cells. A review.

Schizas, Nikitas P; Zafeiris, Christos; Neri, Anna-Aikaterini; Anastasopoulos, Panagiotis P; Papaioannou, Nikolaos A; Dontas, Ismene A

Schizas, Nikitas P; Zafeiris, Christos; Neri, Anna-Aikaterini; Anastasopoulos, Panagiotis P; Papaioannou, Nikolaos A; Dontas, Ismene A.

Afiliación

Schizas NP; School of Medicine, National and Kapodistrian University of Athens.
Zafeiris C; School of Medicine, National and Kapodistrian University of Athens.
Neri AA; School of Medicine, National and Kapodistrian University of Athens.
Anastasopoulos PP; Royal Berkshire Hospital NHS FT.
Papaioannou NA; School of Medicine, National and Kapodistrian University of Athens.
Dontas IA; School of Medicine, National and Kapodistrian University of Athens.

Orthop Rev (Pavia) ; 13(2): 27098, 2021.

Article en En | MEDLINE | ID: mdl-34745485

RESUMEN

Canonical Wnt signaling regulation is essential for controlling stemness and differentiation of mesenchymal stem cells (MSCs). However, the mechanism through which canonical Wnt-dependent MSC lineage commitment leads to chondrogenesis is controversial. Some studies hypothesize that inhibition of canonical Wnt signaling induces MSC chondrogenic differentiation, while others support that the pathway should be activated to achieve MSC chondrogenesis. The purpose of the present review is to analyze data from recent studies to elucidate parameters regarding the role of canonical Wnt signaling in MSC chondrogenic differentiation.

Palabras clave

canonical wnt signaling; chondrogenesis; differentiation; mesenchymal stem cells

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Orthop Rev (Pavia) Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos

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