Amyloid beta increases ABCA1 and HMGCR protein expression, and cholesterol synthesis and accumulation in mice neurons and astrocytes.

Azizidoost, Shirin; Babaahmadi-Rezaei, Hossein; Nazeri, Zahra; Cheraghzadeh, Maryam; Kheirollah, Alireza

Azizidoost, Shirin; Babaahmadi-Rezaei, Hossein; Nazeri, Zahra; Cheraghzadeh, Maryam; Kheirollah, Alireza.

Afiliación

Azizidoost S; Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Babaahmadi-Rezaei H; Department of Biochemistry, Medical School, Cellular & Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Nazeri Z; Department of Biochemistry, Medical School, Cellular & Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Cheraghzadeh M; Department of Biochemistry, Medical School, Cellular & Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Kheirollah A; Department of Biochemistry, Medical School, Cellular & Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address: akheirollah@ajums.ac.ir.

Biochim Biophys Acta Mol Cell Biol Lipids ; 1867(1): 159069, 2022 01.

Article en En | MEDLINE | ID: mdl-34744007

Asunto(s)

Transportador 1 de Casete de Unión a ATP/genética; Enfermedad de Alzheimer/genética; Péptidos beta-Amiloides/genética; Colesterol/metabolismo; Hidroximetilglutaril-CoA Reductasas/genética; Enfermedad de Alzheimer/metabolismo; Enfermedad de Alzheimer/patología; Péptidos beta-Amiloides/metabolismo; Animales; Astrocitos/metabolismo; Astrocitos/patología; Encéfalo/metabolismo; Encéfalo/patología; Colesterol/genética; Regulación de la Expresión Génica/genética; Humanos; Metabolismo de los Lípidos/genética; Lipogénesis/genética; Ratones; Neuronas/metabolismo; Neuronas/patología

Palabras clave

Alzheimer's disease; Amyloid-beta; Astrocytes; Brain apoE; Cholesterol; Neuron

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colesterol / Péptidos beta-Amiloides / Enfermedad de Alzheimer / Transportador 1 de Casete de Unión a ATP / Hidroximetilglutaril-CoA Reductasas Límite: Animals / Humans Idioma: En Revista: Biochim Biophys Acta Mol Cell Biol Lipids Año: 2022 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos

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