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Increased diversity, fungal burden, and virulence of oral Candida spp. in patients undergoing anti-tuberculosis treatment.
Orlandini, Renata Klemp; Rocha, Amanda Carolina Souza Delfino; Silva, Gilberto André; Watanabe, Evandro; Motta, Ana Carolina Fragoso; Silva-Lovato, Claúdia Helena; Oliveira, Viviane de Cássia; Bollela, Valdes Roberto; Lourenço, Alan Grupioni.
Afiliación
  • Orlandini RK; Department of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, Brazil.
  • Rocha ACSD; Department of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, Brazil.
  • Silva GA; Department of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, Brazil.
  • Watanabe E; Department of Restorative Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo, Brazil.
  • Motta ACF; Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto School of Dentistry, University of São Paulo, Brazil.
  • Silva-Lovato CH; Department of Dental Materials and Prosthesis, Ribeirão Preto School of Dentistry, University of São Paulo, Brazil.
  • Oliveira VC; Department of Dental Materials and Prosthesis, Ribeirão Preto School of Dentistry, University of São Paulo, Brazil.
  • Bollela VR; Department of Internal Medicine, Ribeirão Preto School of Medicine, University of São Paulo, Brazil.
  • Lourenço AG; Department of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, Brazil. Electronic address: lourenco@forp.usp.br.
Microb Pathog ; 161(Pt A): 105280, 2021 Dec.
Article en En | MEDLINE | ID: mdl-34742893
Some studies have demonstrated a high prevalence of Candida species in patients with tuberculosis (TB). This is most likely due to long-term antimicrobial therapy. To date, no longitudinal studies addressed the effects of anti-TB treatment on the fungal burden and virulence of Candida spp. This study investigated the prevalence and virulence of Candida spp. in the oral cavity of 30 TB patients at different stages of treatment through a cohort study. These results were compared with those of 60 systemically healthy individuals in a cross-sectional study. Oral rinse samples from TB patients were collected before 45 and after 120 days of treatment. In the control group, the biological samples were collected only once. Candida spp. were identified by restriction fragment length polymorphism (RFLP) assays, and the following virulence factors were studied: phospholipase C and proteinase production, as well as Candida spp. biofilm and hyphae formation. The clinical diagnosis of TB and its treatment time were associated with the greater fungal burden (p < 0.0001), presence of non-albicans Candida (NAC) species (p = 0.0003), and increased virulence factors when compared with the Candida spp. isolated from systemically healthy individuals. The results showed that anti-TB treatment time was responsible for the increased fungal burden and isolation of NAC in TB patients (p = 0.0233). The increased prevalence, quantification, and virulence of Candida spp. isolated from the oral cavity of TB patients highlight the greater risk of oral lesions and cases of systemic dissemination in these patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida / Biopelículas / Antituberculosos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Microb Pathog Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida / Biopelículas / Antituberculosos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Microb Pathog Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido