The effect of bromhexine on the kidney lesions in NZB-NZW-F1 mice.
Scand J Rheumatol Suppl
; 61: 286-90, 1986.
Article
en En
| MEDLINE
| ID: mdl-3473646
The NZB-NZW-F1 mice develop a clinical picture resembling SLE and an exocrinopathy resembling Sjögren's syndrome. Three groups of hybrids were treated from their 20th week of age for 10, 17 and 20 weeks (groups 1, 2, 3) with Bromhexine in two different concentrations--6 & 60 mg/kg and placebo. NMRJ mice treated with placebo acted as healthy controls. After the treatment the kidneys were examined by light microscopy. The kidneys exhibited lupus-like lesions. Animals treated with 60 mg/kg Bromhexine for 17 weeks had a significantly lower degree of changes than had the other hybrids.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bromhexina
/
Síndrome de Sjögren
/
Modelos Animales de Enfermedad
/
Glomerulonefritis
Tipo de estudio:
Clinical_trials
/
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Scand J Rheumatol Suppl
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Noruega