LCCL peptide cleavage after noise exposure exacerbates hearing loss and is associated with the monocyte infiltration in the cochlea.

Bae, Seong Hoon; Yoo, Jee Eun; Hong, Ji Won; Park, Haeng Ran; Noh, Byunghwa; Kim, Hyoyeol; Kang, Minjin; Hyun, Young-Min; Gee, Heon Yung; Choi, Jae Young; Jung, Jinsei

Bae, Seong Hoon; Yoo, Jee Eun; Hong, Ji Won; Park, Haeng Ran; Noh, Byunghwa; Kim, Hyoyeol; Kang, Minjin; Hyun, Young-Min; Gee, Heon Yung; Choi, Jae Young; Jung, Jinsei.

Afiliación

Bae SH; Department of Otorhinolaryngology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea.
Yoo JE; Department of Otorhinolaryngology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea.
Hong JW; Department of Pharmacology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea.
Park HR; Department of Otorhinolaryngology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea.
Noh B; Department of Otorhinolaryngology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kim H; Department of Otorhinolaryngology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kang M; Department of Otorhinolaryngology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea.
Hyun YM; Department of Anatomy, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea.
Gee HY; Department of Pharmacology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea.
Choi JY; Department of Otorhinolaryngology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea.
Jung J; Department of Otorhinolaryngology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: jsjung@yuhs.ac.

Hear Res ; 412: 108378, 2021 12.

Article en En | MEDLINE | ID: mdl-34735822

Asunto(s)

Pérdida Auditiva Provocada por Ruido; Monocitos; Animales; Cóclea; Proteínas de la Matriz Extracelular/genética; Glicoproteínas; Ratones; Péptidos

Palabras clave

AIED, Autoimmune Inner Ear Disease; Acoustic trauma, animal study, inflammatory response, LCCL peptide, noise-induced hearing loss, Abbreviations, ABR, auditory brainstem response; CCL2, C-C motif chemokine ligand 2; DEGs, differentially expressed genes; EDTA, ethylenediaminetetraacetic acid; IL-1ß, interleukin-1ß; IL-6, interleukin-6; KO, knock-out; LCCL, Limulus factor C, Cochlin, and Lgl1; NIHL, noise-induced hearing loss; RNA-seq, RNA sequencing; RT-PCR, real-time polymerase chain reaction; SDS, sodium dodecyl sulfate; SPL, sound pressure level; Tnf-α, tumor necrosis factor alpha

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Monocitos / Pérdida Auditiva Provocada por Ruido Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Hear Res Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos

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