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Lifestyle-Induced Redox-Sensitive Alterations: Cross-Talk among the RAAS, Antioxidant/Inflammatory Status, and Hypertension.
Szabó, Renáta; Börzsei, Denise; Hoffmann, Alexandra; Lesi, Zelma Nadin; Gesztelyi, Rudolf; Juhász, Béla; Szebeni, Gábor J; Osman, Jasmin; Sebestyén, Judith; Nagy, Arnold; Szegedi, Sándor; Varga, Csaba; Pósa, Anikó.
Afiliación
  • Szabó R; Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.
  • Börzsei D; Interdisciplinary Excellence Centre, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, Hungary.
  • Hoffmann A; Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.
  • Lesi ZN; Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.
  • Gesztelyi R; HR-Pharma Ltd., Szeged, Hungary.
  • Juhász B; Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.
  • Szebeni GJ; Department of Pharmacology and Pharmacotherapy, University of Debrecen, H-4032 Debrecen, Hungary.
  • Osman J; Department of Pharmacology and Pharmacotherapy, University of Debrecen, H-4032 Debrecen, Hungary.
  • Sebestyén J; Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.
  • Nagy A; Laboratory of Functional Genomics, Institute of Genetics, Biological Research Centre, Hungarian Academy of Sciences, Szeged H-6726, Hungary.
  • Szegedi S; Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.
  • Varga C; South-Pest Hospital Centre, National Institute for Infectology and Haematology, Department of Burns and Plastic Surgery, Budapest H-1097, Hungary.
  • Pósa A; Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.
Oxid Med Cell Longev ; 2021: 3080863, 2021.
Article en En | MEDLINE | ID: mdl-34733402
The development and progression of hypertension are closely linked to an unhealthy lifestyle; however, its underlying mechanisms are not fully elucidated. Our aim was to assess the effects of diet and exercise on the elements of the renin-angiotensin-aldosterone system (RAAS), redox-sensitive parameters, and the expression of the vascular tone regulator endothelial nitric oxide synthase (eNOS). Male control Wistar-Kyoto (WKY) and stroke-prone spontaneously hypertensive (SHRSP) rats were randomized based on the type of diet (standard chow, high-fat diet: HT, and fructose-enriched diet: HF) and exercise (voluntary wheel-running exercise or lack of exercise). After 12 weeks of experimental period, the concentrations of the RAAS elements, myeloperoxidase (MPO) activity, tumor necrosis factor alpha (TNF-α) concentrations, levels of superoxide dismutase (SOD) and glutathione (GSH), and expressions of extracellular signal-regulated kinase1/2 (ERK1/2) and phosphorylated ERK1/2 as well as eNOS were measured in the cardiac tissue of WKY and SHRSP rats. We found that the RAAS elements were overactivated under hypertension and were further elevated by HT or HF diet, while HT and HF diet enhanced MPO and TNF-α parameters as well as the expression of pERK1/2; SOD, GSH, and eNOS levels were decreased. These changes occurred in WKKY rats and reached the statistically significant level in SHRSP animals. 12 weeks of exercise compensated the adverse effects of HT and HF via alleviating the concentrations of the RAAS elements and inflammatory markers as well as increasing of antioxidants. Our findings prove that SHRSP rats are more vulnerable to lifestyle changes. Both the type of diet and exercise, as a nonpharmacological therapeutic tool, can have a significant impact on the progression of hypertension.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Renina-Angiotensina / Presión Sanguínea / Óxido Nítrico Sintasa de Tipo III / Hipertensión / Inflamación / Estilo de Vida / Antioxidantes Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2021 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Renina-Angiotensina / Presión Sanguínea / Óxido Nítrico Sintasa de Tipo III / Hipertensión / Inflamación / Estilo de Vida / Antioxidantes Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2021 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Estados Unidos