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A medullary centre for lapping in mice.
Dempsey, Bowen; Sungeelee, Selvee; Bokiniec, Phillip; Chettouh, Zoubida; Diem, Séverine; Autran, Sandra; Harrell, Evan R; Poulet, James F A; Birchmeier, Carmen; Carey, Harry; Genovesio, Auguste; McMullan, Simon; Goridis, Christo; Fortin, Gilles; Brunet, Jean-François.
Afiliación
  • Dempsey B; Institut de Biologie de l'ENS (IBENS), Inserm, CNRS, École normale supérieure, PSL Research University, Paris, France.
  • Sungeelee S; Institut de Biologie de l'ENS (IBENS), Inserm, CNRS, École normale supérieure, PSL Research University, Paris, France.
  • Bokiniec P; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), and Neuroscience Research Center, Charité-Universitätsmedizin, Berlin, Germany.
  • Chettouh Z; Institut de Biologie de l'ENS (IBENS), Inserm, CNRS, École normale supérieure, PSL Research University, Paris, France.
  • Diem S; Université Paris-Saclay, CNRS, Institut des Neurosciences NeuroPSI, Gif-sur-Yvette, France.
  • Autran S; Université Paris-Saclay, CNRS, Institut des Neurosciences NeuroPSI, Gif-sur-Yvette, France.
  • Harrell ER; Institut Pasteur, INSERM, Institut de l'Audition, Paris, France.
  • Poulet JFA; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), and Neuroscience Research Center, Charité-Universitätsmedizin, Berlin, Germany.
  • Birchmeier C; Developmental Biology/Signal Transduction, Max Delbrueck Center for Molecular Medicine, and Cluster of Excellence NeuroCure, Neuroscience Research Center, Charité-Universitätsmedizin, Berlin, Germany.
  • Carey H; Faculty of Medicine, Health & Human Sciences, Macquarie University, Macquarie Park, NSW, Australia.
  • Genovesio A; Institut de Biologie de l'ENS (IBENS), Inserm, CNRS, École normale supérieure, PSL Research University, Paris, France.
  • McMullan S; Faculty of Medicine, Health & Human Sciences, Macquarie University, Macquarie Park, NSW, Australia.
  • Goridis C; Institut de Biologie de l'ENS (IBENS), Inserm, CNRS, École normale supérieure, PSL Research University, Paris, France.
  • Fortin G; Institut de Biologie de l'ENS (IBENS), Inserm, CNRS, École normale supérieure, PSL Research University, Paris, France.
  • Brunet JF; Institut de Biologie de l'ENS (IBENS), Inserm, CNRS, École normale supérieure, PSL Research University, Paris, France. jfbrunet@biologie.ens.fr.
Nat Commun ; 12(1): 6307, 2021 11 02.
Article en En | MEDLINE | ID: mdl-34728601
It has long been known that orofacial movements for feeding can be triggered, coordinated, and often rhythmically organized at the level of the brainstem, without input from higher centers. We uncover two nuclei that can organize the movements for ingesting fluids in mice. These neuronal groups, IRtPhox2b and Peri5Atoh1, are marked by expression of the pan-autonomic homeobox gene Phox2b and are located, respectively, in the intermediate reticular formation of the medulla and around the motor nucleus of the trigeminal nerve. They are premotor to all jaw-opening and tongue muscles. Stimulation of either, in awake animals, opens the jaw, while IRtPhox2b alone also protracts the tongue. Moreover, stationary stimulation of IRtPhox2b entrains a rhythmic alternation of tongue protraction and retraction, synchronized with jaw opening and closing, that mimics lapping. Finally, fiber photometric recordings show that IRtPhox2b is active during volitional lapping. Our study identifies one of the subcortical nuclei underpinning a stereotyped feeding behavior.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lengua / Factores de Transcripción / Tronco Encefálico / Bulbo Raquídeo / Proteínas de Homeodominio / Conducta Alimentaria / Maxilares / Neuronas Motoras Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lengua / Factores de Transcripción / Tronco Encefálico / Bulbo Raquídeo / Proteínas de Homeodominio / Conducta Alimentaria / Maxilares / Neuronas Motoras Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido