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Rnd3 is necessary for the correct oligodendrocyte differentiation and myelination in the central nervous system.
Madrigal, M P; Ballester-Lurbe, B; Gómez, O; Moreno-Bravo, J A; Puelles, E; Jurado, S; Garcia-Verdugo, J M; Pérez-Roger, I; Terrado, José.
Afiliación
  • Madrigal MP; Departamento de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad CEU Cardenal Herrera, CEU Universities, Alfara del Patriarca, Valencia, Spain.
  • Ballester-Lurbe B; Departamento de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad CEU Cardenal Herrera, CEU Universities, Alfara del Patriarca, Valencia, Spain.
  • Gómez O; Departamento de Medicina y Cirugía Animal, Facultad de Veterinaria, Universidad CEU Cardenal Herrera, CEU Universities, Alfara del Patriarca, Valencia, Spain.
  • Moreno-Bravo JA; Instituto de Neurociencias CSIC-UMH, San Juan de Alicante, Spain.
  • Puelles E; Instituto de Neurociencias CSIC-UMH, San Juan de Alicante, Spain.
  • Jurado S; Instituto de Neurociencias CSIC-UMH, San Juan de Alicante, Spain.
  • Garcia-Verdugo JM; Laboratorio de Neurobiologia Comparada, Instituto Cavanilles de Biodiversidad y Biologia Evolutiva, Universidad de Valencia and CIBER de Enfermedades Neurodegenerativas (CIBERNED), Valencia, Spain.
  • Pérez-Roger I; Departamento de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad CEU Cardenal Herrera, CEU Universities, Alfara del Patriarca, Valencia, Spain.
  • Terrado J; Departamento de Medicina y Cirugía Animal, Facultad de Veterinaria, Universidad CEU Cardenal Herrera, CEU Universities, Alfara del Patriarca, Valencia, Spain. jterrado@uchceu.es.
Brain Struct Funct ; 227(3): 829-841, 2022 Apr.
Article en En | MEDLINE | ID: mdl-34724108
Rho small GTPases are proteins with key roles in the development of the central nervous system. Rnd proteins are a subfamily of Rho GTPases, characterized by their constitutive activity. Rnd3/RhoE is a member of this subfamily ubiquitously expressed in the CNS, whose specific functions during brain development are still not well defined. Since other Rho proteins have been linked to the myelination process, we study here the expression and function of Rnd3 in oligodendrocyte development. We have found that Rnd3 is expressed in a subset of oligodendrocyte precursor cells and of mature oligodendrocytes both in vivo and in vitro. We have analyzed the role of Rnd3 in myelination using mice lacking Rnd3 expression (Rnd3gt/gt mice), showing that these mice exhibit hypomyelination in the brain and a reduction in the number of mature and total oligodendrocytes in the corpus callosum and striatum. The mutants display a decreased expression of several myelin proteins and a reduction in the number of myelinated axons. In addition, myelinated axons exhibit thinner myelin sheaths. In vitro experiments using Rnd3gt/gt mutant mice showed that the differentiation of the precursor cells is altered in the absence of Rnd3 expression, suggesting that Rnd3 is directly required for the differentiation of oligodendrocytes and, in consequence, for the correct myelination of the CNS. This work shows Rnd3 as a new protein involved in oligodendrocyte maturation, opening new avenues to further study the function of Rnd3 in the development of the central nervous system and its possible involvement in demyelinating diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligodendroglía / Vaina de Mielina Límite: Animals Idioma: En Revista: Brain Struct Funct Asunto de la revista: CEREBRO Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligodendroglía / Vaina de Mielina Límite: Animals Idioma: En Revista: Brain Struct Funct Asunto de la revista: CEREBRO Año: 2022 Tipo del documento: Article País de afiliación: España Pais de publicación: Alemania