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Neuromelanin accumulation in patients with schizophrenia: A systematic review and meta-analysis.
Ueno, Fumihiko; Iwata, Yusuke; Nakajima, Shinichiro; Caravaggio, Fernando; Rubio, Jose M; Horga, Guillermo; Cassidy, Clifford M; Torres-Carmona, Edgardo; de Luca, Vincenzo; Tsugawa, Sakiko; Honda, Shiori; Moriguchi, Sho; Noda, Yoshihiro; Gerretsen, Philip; Graff-Guerrero, Ariel.
Afiliación
  • Ueno F; Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
  • Iwata Y; Department of Neuropsychiatry, University of Yamanashi, Faculty of Medicine, Yamanashi, Japan.
  • Nakajima S; Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan. Electronic address: shinichiro_nakajima@hotmail.com.
  • Caravaggio F; Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
  • Rubio JM; Barbara and Donald Zucker School of Medicine at Hofstra University - Northwell Health, Hempstead, NY, USA; Institute of Behavioral Science, Feinstein Institutes of Medical Research, Manhasset, NY, USA; Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, NY, USA.
  • Horga G; Department of Psychiatry, Columbia University, New York, NY, USA; Division of Translational Imaging, New York State Psychiatric Institute, New York, NY, USA.
  • Cassidy CM; The Royal's Institute of Mental Health Research Affiliated with the University of Ottawa, Ottawa, Ontario, Canada.
  • Torres-Carmona E; Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
  • de Luca V; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Campbell Family Mental Health Research Institute, CAMH, Toronto, Ontario, Canada.
  • Tsugawa S; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
  • Honda S; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
  • Moriguchi S; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
  • Noda Y; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
  • Gerretsen P; Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Campbell Family Mental Health Research Insti
  • Graff-Guerrero A; Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Campbell Family Mental Health Research Insti
Neurosci Biobehav Rev ; 132: 1205-1213, 2022 01.
Article en En | MEDLINE | ID: mdl-34718049
Although schizophrenia is associated with increased presynaptic dopamine function in the striatum, it remains unclear if neuromelanin levels, which are thought to serve as a biomarker for midbrain dopamine neuron function, are increased in patients with schizophrenia. We conducted a systematic review and meta-analysis of magnetic resonance imaging (MRI) and postmortem studies comparing neuromelanin (NM) levels between patients with schizophrenia and healthy controls (HCs). Standard mean differences were calculated to assess group differences in NM accumulation levels between patients with schizophrenia and HCs. This study included 7 articles in total. Five studies employed NM-sensitive MRI (NM-MRI) and two were postmortem brain studies. The patient group (n = 163) showed higher NM levels in the substantia nigra (SN) than HCs (n = 228) in both the analysis of the seven studies and the subgroup analysis of the 5 NM-MRI studies. This analysis suggest increased NM levels in the SN may be a potential biomarker for stratifying schizophrenia, warranting further research that accounts for the heterogeneity of this disorder.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Neurosci Biobehav Rev Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Neurosci Biobehav Rev Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos