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Effect of vinyl chloride exposure on cardiometabolic toxicity.
Zelko, Igor N; Taylor, Breandon S; Das, Trinath P; Watson, Walter H; Sithu, Israel D; Wahlang, Banrida; Malovichko, Marina V; Cave, Matthew C; Srivastava, Sanjay.
Afiliación
  • Zelko IN; Superfund Research Center, University of Louisville, Kentucky, USA.
  • Taylor BS; Envirome Institute, University of Louisville, Kentucky, USA.
  • Das TP; Department of Medicine, Division of Environmental Medicine, University of Louisville, Kentucky, USA.
  • Watson WH; Superfund Research Center, University of Louisville, Kentucky, USA.
  • Sithu ID; Envirome Institute, University of Louisville, Kentucky, USA.
  • Wahlang B; Department of Medicine, Division of Environmental Medicine, University of Louisville, Kentucky, USA.
  • Malovichko MV; Department of Pharmacology and Toxicology, University of Louisville, Kentucky, USA.
  • Cave MC; Superfund Research Center, University of Louisville, Kentucky, USA.
  • Srivastava S; Envirome Institute, University of Louisville, Kentucky, USA.
Environ Toxicol ; 37(2): 245-255, 2022 Feb.
Article en En | MEDLINE | ID: mdl-34717031
Vinyl chloride (VC) is an organochlorine mainly used to manufacture its polymer polyvinyl chloride, which is extensively used in the manufacturing of consumer products. Recent studies suggest that chronic low dose VC exposure affects glucose homeostasis in high fat diet-fed mice. Our data suggest that even in the absence of high fat diet, exposure to VC (0.8 ppm, 6 h/day, 5 day/week, for 12 weeks) induces glucose intolerance (1.0 g/kg, i.p.) in male C57BL/6 mice. This was accompanied with the depletion of hepatic glutathione and a modest increase in lung interstitial macrophages. VC exposure did not affect the levels of circulating immune cells, endothelial progenitor cells, platelet-immune cell aggregates, and cytokines and chemokines. The acute challenge of VC-exposed mice with LPS did not affect lung immune cell composition or plasma IL-6. To examine the effect of VC exposure on vascular inflammation and atherosclerosis, LDL receptor-KO mice on C57BL/6 background maintained on western diet were exposed to VC for 12 weeks (0.8 ppm, 6 h/day, 5 day/week). Unlike the WT C57BL/6 mice, VC exposure did not affect glucose tolerance in the LDL receptor-KO mice. Plasma cytokines, lesion area in the aortic valve, and markers of lesional inflammation in VC-exposed LDL receptor-KO mice were comparable with the air-exposed controls. Collectively, despite impaired glucose tolerance and modest pulmonary inflammation, chronic low dose VC exposure does not affect surrogate markers of cardiovascular injury, LPS-induced acute inflammation in C57BL/6 mice, and chronic inflammation and atherosclerosis in the LDL receptor-KO mice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cloruro de Vinilo / Enfermedades Cardiovasculares Límite: Animals Idioma: En Revista: Environ Toxicol Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cloruro de Vinilo / Enfermedades Cardiovasculares Límite: Animals Idioma: En Revista: Environ Toxicol Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos