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Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells.
Sun, Yadong; Berleth, Niklas; Wu, Wenxian; Schlütermann, David; Deitersen, Jana; Stuhldreier, Fabian; Berning, Lena; Friedrich, Annabelle; Akgün, Seda; Mendiburo, María José; Wesselborg, Sebastian; Conrad, Marcus; Berndt, Carsten; Stork, Björn.
Afiliación
  • Sun Y; Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Berleth N; Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Wu W; Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Schlütermann D; Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Deitersen J; Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Stuhldreier F; Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Berning L; Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Friedrich A; Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Akgün S; Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Mendiburo MJ; Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Wesselborg S; Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
  • Conrad M; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany.
  • Berndt C; Pirogov Russian National Research Medical University, Laboratory of Experimental Oncology, Ostrovityanova 1, Moscow, 117997, Russia.
  • Stork B; Department of Neurology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
Cell Death Dis ; 12(11): 1028, 2021 10 29.
Article en En | MEDLINE | ID: mdl-34716292
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oximas / Autofagia / Sulfonamidas / Neoplasias de la Vejiga Urinaria / Transducción de Señal / Proteolisis / Ferroptosis / Fosfolípido Hidroperóxido Glutatión Peroxidasa / Inhibidores mTOR / Naftiridinas Límite: Humans Idioma: En Revista: Cell Death Dis Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oximas / Autofagia / Sulfonamidas / Neoplasias de la Vejiga Urinaria / Transducción de Señal / Proteolisis / Ferroptosis / Fosfolípido Hidroperóxido Glutatión Peroxidasa / Inhibidores mTOR / Naftiridinas Límite: Humans Idioma: En Revista: Cell Death Dis Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido