Insertion-trigger residues differentially modulate endosomal escape by cytotoxic necrotizing factor toxins.

Haywood, Elizabeth E; Handy, Nicholas B; Lopez, James W; Ho, Mengfei; Wilson, Brenda A

Haywood, Elizabeth E; Handy, Nicholas B; Lopez, James W; Ho, Mengfei; Wilson, Brenda A.

Afiliación

Haywood EE; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Handy NB; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Lopez JW; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Ho M; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Wilson BA; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. Electronic address: wilson7@illinois.edu.

J Biol Chem ; 297(5): 101347, 2021 11.

Article en En | MEDLINE | ID: mdl-34715130

Asunto(s)

Toxinas Bacterianas; Endosomas/metabolismo; Proteínas de Escherichia coli; Lisosomas/metabolismo; Toxinas Bacterianas/genética; Toxinas Bacterianas/metabolismo; Endosomas/genética; Proteínas de Escherichia coli/genética; Proteínas de Escherichia coli/metabolismo; Células HEK293; Humanos; Lisosomas/genética; Dominios Proteicos; Transporte de Proteínas

Palabras clave

bacterial toxin; drug delivery system; fusion protein; molecular evolution; protein chimera; protein deamidation; protein engineering; protein translocation; small GTPase; structurefunction

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endosomas / Toxinas Bacterianas / Proteínas de Escherichia coli / Lisosomas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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