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Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy.
Blazkova, Jana; Gao, Feng; Marichannegowda, Manukumar Honnayakanahalli; Justement, J Shawn; Shi, Victoria; Whitehead, Emily J; Schneck, Rachel F; Huiting, Erin D; Gittens, Kathleen; Cottrell, Mackenzie; Benko, Erika; Kovacs, Colin; Lack, Justin; Sneller, Michael C; Moir, Susan; Fauci, Anthony S; Chun, Tae-Wook.
Afiliación
  • Blazkova J; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Gao F; Department of Medicine, Duke University, Durham, NC, USA.
  • Marichannegowda MH; Jinan University School of Medicine, Guangzhou, China.
  • Justement JS; Department of Medicine, Duke University, Durham, NC, USA.
  • Shi V; Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Whitehead EJ; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Schneck RF; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Huiting ED; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Gittens K; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Cottrell M; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Benko E; Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
  • Kovacs C; Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina, Chapel Hill, NC, USA.
  • Lack J; Maple Leaf Medical Clinic, Toronto ON, Canada.
  • Sneller MC; Maple Leaf Medical Clinic, Toronto ON, Canada.
  • Moir S; NIAID Collaborative Bioinformatics Resource, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Fauci AS; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Chun TW; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Nat Med ; 27(11): 1893-1898, 2021 11.
Article en En | MEDLINE | ID: mdl-34711975
Certain infected individuals suppress human immunodeficiency virus (HIV) in the absence of anti-retroviral therapy (ART). Elucidating the underlying mechanism(s) is of high interest. Here we present two contrasting case reports of HIV-infected individuals who controlled plasma viremia for extended periods after undergoing analytical treatment interruption (ATI). In Participant 04, who experienced viral blips and initiated undisclosed self-administration of suboptimal ART detected shortly before day 1,250, phylogenetic analyses of plasma HIV env sequences suggested continuous viral evolution and/or reactivation of pre-existing viral reservoirs over time. Antiviral CD8+ T cell activities were higher in Participant 04 than in Participant 30. In contrast, Participant 30 exhibited potent plasma-IgG-mediated neutralization activity against autologous virus that became ineffective when he experienced sudden plasma viral rebound 1,434 d after ATI due to HIV superinfection. Our data provide insight into distinct mechanisms of post-treatment interruption control and highlight the importance of frequent monitoring of undisclosed use of ART and superinfection during the ATI phase.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 / Cooperación del Paciente / Linfocitos T CD8-positivos / Fármacos Anti-VIH / Anticuerpos Antivirales Tipo de estudio: Clinical_trials Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 / Cooperación del Paciente / Linfocitos T CD8-positivos / Fármacos Anti-VIH / Anticuerpos Antivirales Tipo de estudio: Clinical_trials Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos