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A scoping review of global aminoglycoside antibiotic overuse: A potential opportunity for primary ototoxicity prevention.
Dillard, Lauren K; Wu, Cecilia Z; Saunders, James E; McMahon, Catherine M.
Afiliación
  • Dillard LK; Department of Population Health Sciences, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: lauren.dillard@wisc.edu.
  • Wu CZ; Mass General Brigham Home Care, Department of Staff Education, Waltham, MA, USA.
  • Saunders JE; Section of Otolaryngology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA; Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
  • McMahon CM; Department of Linguistics, Macquarie University, Sydney, New South Wales, Australia.
Res Social Adm Pharm ; 18(8): 3220-3229, 2022 08.
Article en En | MEDLINE | ID: mdl-34711521
BACKGROUND: Aminoglycosides are widely used, broad-spectrum antibiotics with significant potential for ototoxicity. Global efforts to prevent ototoxicity must account for aminoglycoside overuse and non-prescription use. OBJECTIVES: The goals of this study were to a) estimate the prevalence of aminoglycoside overuse by synthesizing evidence on self-medication, over the counter (OTC) availability, and household antibiotic storage for later use, and to report the specific aminoglycosides used and the predictors of overuse, and b) leverage this information to comment on potential risk of ototoxicity. METHODS: Two systematic search strings were conducted to extract peer-reviewed articles published from 2005 to 2020. The first focused on overuse of aminoglycoside antibiotics. The second focused on potentially ototoxic effects of aminoglycosides related to drug overuse. RESULTS: A total of 26 articles were included (first search string: n = 21; second search string: n = 5). The prevalence of aminoglycoside self-medication was high and household storage and OTC availability of aminoglycosides was common. Gentamicin was the most commonly overused aminoglycoside. No studies provided information on antibiotic dosing or resultant toxicities, including ototoxicity. CONCLUSIONS: The limited available evidence indicates that antibiotic overuse (self-medication, home storage, and non-prescription availability) is relatively common, especially in low resource settings, and that aminoglycoside antibiotics comprise a variable, but concerning, proportion of non-prescribed antibiotics. Additional evidence is needed to evaluate the relationship between these dispensing patterns and ototoxicity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Uso Excesivo de Medicamentos Recetados / Ototoxicidad / Aminoglicósidos / Antibacterianos Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Res Social Adm Pharm Asunto de la revista: FARMACIA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Uso Excesivo de Medicamentos Recetados / Ototoxicidad / Aminoglicósidos / Antibacterianos Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Res Social Adm Pharm Asunto de la revista: FARMACIA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos