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Response to extracorporeal photopheresis therapy of patients with steroid-refractory/-resistant GvHD is associated with up-regulation of Th22 cells and Tfh cells.
Ni, Ming; Wang, Lei; Ding, Yuntian; Gong, Wenjie; Wang, Sanmei; Neuber, Brigitte; Schubert, Maria-Luisa; Sauer, Tim; Hückelhoven-Krauss, Angela; Luft, Thomas; Hegenbart, Ute; Schönland, Stefan; Eckstein, Volker; Wang, Jishi; Krüger, William; Müller-Tidow, Carsten; Dreger, Peter; Schmitt, Michael; Schmitt, Anita.
Afiliación
  • Ni M; Department of Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany; Department of Hematology, the Affiliated Hospital of Guizhou Medical University, Guizhou, China.
  • Wang L; Department of Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany.
  • Ding Y; Department of Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany.
  • Gong W; Department of Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany; Department of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, China.
  • Wang S; Department of Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany; Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, China.
  • Neuber B; Department of Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany.
  • Schubert ML; Department of Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany.
  • Sauer T; Department of Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany.
  • Hückelhoven-Krauss A; Department of Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany.
  • Luft T; Department of Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany.
  • Hegenbart U; Department of Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany.
  • Schönland S; Department of Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany.
  • Eckstein V; Department of Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany.
  • Wang J; Department of Hematology, the Affiliated Hospital of Guizhou Medical University, Guizhou, China.
  • Krüger W; Department of Internal Medicine C, Haematology, Oncology, Stem Cell Transplantation, Palliative Care, University Clinic Greifswald, Greifswald, Germany.
  • Müller-Tidow C; Department of Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany.
  • Dreger P; Department of Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany.
  • Schmitt M; Department of Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany.
  • Schmitt A; Department of Internal Medicine V, University Clinic Heidelberg, Heidelberg, Germany. Electronic address: anita.schmitt@med.uni-heidelberg.de.
Cytotherapy ; 24(3): 311-319, 2022 03.
Article en En | MEDLINE | ID: mdl-34711501
Extracorporeal photopheresis (ECP), a personalized cellular immunotherapy, constitutes a promising treatment for steroid-refractory/-resistant graft-versus-host disease (SR-GvHD), with encouraging clinical response rates. To further investigate its mechanism of action, ECP's effects on T helper (Th) cells as well as on expression of immune checkpoint (PD-1 and Tim-3) and apoptotic (Fas receptor [FasR]) molecules were investigated in 27 patients with SR-GvHD. Our data show that GvHD patients had significantly higher levels of Th2, Th17, Th22 and granulocyte-macrophage colony-stimulating factor (GM-CSF)-positive Th (ThG) cells and clearly lower levels of T follicular helper (Tfh) cells, including Th1- and Th2-like cells, compared with healthy donors. ECP therapy for GvHD was effective through the modulation of different Th subsets: increases of Th22 (1.52-fold) and Tfh cells (1.48-fold) in acute GvHD (aGvHD) and increases of Th2-like Tfh cells (1.74-fold) in chronic GvHD (cGvHD) patients were associated with clinical response. Expression of FasR was further upregulated in CD4+CD8+ T cells. Additionally, Tim-3-expressing effector T cells associated with the severity of GvHD were reduced. Taken together, these data show that ECP therapy exerts immunomodulatory effects by promoting a balanced immune reconstitution and inducing immune tolerance. Therefore it represents an attractive option for the treatment of GvHD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoféresis / Enfermedad Injerto contra Huésped Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Cytotherapy Asunto de la revista: TERAPEUTICA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoféresis / Enfermedad Injerto contra Huésped Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Cytotherapy Asunto de la revista: TERAPEUTICA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido