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Homologous recombination proficiency in ovarian and breast cancer patients.
Creeden, Justin Fortune; Nanavaty, Nisha S; Einloth, Katelyn R; Gillman, Cassidy E; Stanbery, Laura; Hamouda, Danae M; Dworkin, Lance; Nemunaitis, John.
Afiliación
  • Creeden JF; Department of Neurosciences, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
  • Nanavaty NS; Department of Cancer Biology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
  • Einloth KR; Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
  • Gillman CE; Department of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
  • Stanbery L; Department of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
  • Hamouda DM; Department of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
  • Dworkin L; Gradalis, Inc., Carrollton, Carrollton, TX, USA.
  • Nemunaitis J; Department of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
BMC Cancer ; 21(1): 1154, 2021 Oct 28.
Article en En | MEDLINE | ID: mdl-34711195
Homologous recombination and DNA repair are important for genome maintenance. Genetic variations in essential homologous recombination genes, including BRCA1 and BRCA2 results in homologous recombination deficiency (HRD) and can be a target for therapeutic strategies including poly (ADP-ribose) polymerase inhibitors (PARPi). However, response is limited in patients who are not HRD, highlighting the need for reliable and robust HRD testing. This manuscript will review BRCA1/2 function and homologous recombination proficiency in respect to breast and ovarian cancer. The current standard testing methods for HRD will be discussed as well as trials leading to approval of PARPi's. Finally, standard of care treatment and synthetic lethality will be reviewed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Neoplasias de la Mama / Genes BRCA1 / Genes BRCA2 / Reparación del ADN por Recombinación / Recombinación Homóloga Límite: Female / Humans Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Neoplasias de la Mama / Genes BRCA1 / Genes BRCA2 / Reparación del ADN por Recombinación / Recombinación Homóloga Límite: Female / Humans Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido