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Glucocorticoid-induced redistribution lymphocytosis in mantle cell lymphoma with hyaline vascular Castleman disease-like features.
Togitani, Kazuto; Iguchi, Mitsuko; Asagiri, Tadashi; Ogasawara, Fumiya; Murakami, Ichiro; Kojima, Kensuke.
Afiliación
  • Togitani K; Department of Hematology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
  • Iguchi M; Department of Pathology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
  • Asagiri T; Department of Laboratory Medicine, Kochi Medical School Hospital, Nankoku, Kochi, Japan.
  • Ogasawara F; Department of Hematology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
  • Murakami I; Department of Pathology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
  • Kojima K; Department of Hematology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
J Clin Exp Hematop ; 62(1): 46-51, 2022 Mar 09.
Article en En | MEDLINE | ID: mdl-34707036
We report a case of mantle cell lymphoma mimicking Castleman disease. A 76-year-old man presented with generalized lymphadenopathy, splenomegaly, anemia, polyclonal gammopathy, and pulmonary infiltrations. Lymph node biopsy revealed histological features of hyaline vascular Castleman disease. Treatment with prednisolone induced lymphocytosis with immunophenotypic and genetic features of mantle cell lymphoma. A detailed immunohistochemical study of the lymph node demonstrated a mantle cell lymphoma-mantle zone growth pattern. Glucocorticoid-induced distribution lymphocytosis has not been reported in mantle cell lymphoma. Careful observation of circulating lymphocytes during steroid treatment may enable diagnosis of the underlying occult lymphoma in a subset of patients exhibiting clinical manifestations of Castleman disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Castleman / Linfoma de Células del Manto / Linfocitosis Tipo de estudio: Diagnostic_studies Límite: Adult / Humans Idioma: En Revista: J Clin Exp Hematop Asunto de la revista: HEMATOLOGIA / PATOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Castleman / Linfoma de Células del Manto / Linfocitosis Tipo de estudio: Diagnostic_studies Límite: Adult / Humans Idioma: En Revista: J Clin Exp Hematop Asunto de la revista: HEMATOLOGIA / PATOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón