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Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction.
Norton, David; Bonnette, William G; Callahan, James F; Carr, Maria G; Griffiths-Jones, Charlotte M; Heightman, Tom D; Kerns, Jeffrey K; Nie, Hong; Rich, Sharna J; Richardson, Caroline; Rumsey, William; Sanchez, Yolanda; Verdonk, Marcel L; Willems, Henriëtte M G; Wixted, William E; Wolfe, Lawrence; Woolford, Alison J-A; Wu, Zining; Davies, Thomas G.
Afiliación
  • Norton D; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K.
  • Bonnette WG; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426-0989, United States.
  • Callahan JF; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426-0989, United States.
  • Carr MG; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K.
  • Griffiths-Jones CM; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K.
  • Heightman TD; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K.
  • Kerns JK; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426-0989, United States.
  • Nie H; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426-0989, United States.
  • Rich SJ; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K.
  • Richardson C; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K.
  • Rumsey W; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426-0989, United States.
  • Sanchez Y; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426-0989, United States.
  • Verdonk ML; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K.
  • Willems HMG; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K.
  • Wixted WE; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426-0989, United States.
  • Wolfe L; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426-0989, United States.
  • Woolford AJ; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K.
  • Wu Z; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426-0989, United States.
  • Davies TG; Astex Pharmaceuticals, 436 Cambridge Science Park, Cambridge CB4 0QA, U.K.
J Med Chem ; 64(21): 15949-15972, 2021 11 11.
Article en En | MEDLINE | ID: mdl-34705450
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Carboxílicos / Descubrimiento de Drogas / Proteína 1 Asociada A ECH Tipo Kelch Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Carboxílicos / Descubrimiento de Drogas / Proteína 1 Asociada A ECH Tipo Kelch Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos