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Estimating the global burden of Epstein-Barr virus-related cancers.
Wong, Yide; Meehan, Michael T; Burrows, Scott R; Doolan, Denise L; Miles, John J.
Afiliación
  • Wong Y; Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, 4878, Australia. yide.wong@jcu.edu.au.
  • Meehan MT; Centre for Molecular Therapeutics, James Cook University, Cairns, QLD, 4870, Australia. yide.wong@jcu.edu.au.
  • Burrows SR; Centre for Tropical Bioinformatics and Molecular Biology, James Cook University, Cairns, QLD, 4878, Australia. yide.wong@jcu.edu.au.
  • Doolan DL; Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, QLD, 4811, Australia.
  • Miles JJ; QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia.
J Cancer Res Clin Oncol ; 148(1): 31-46, 2022 Jan.
Article en En | MEDLINE | ID: mdl-34705104
BACKGROUND: More than 90% of the adult population globally is chronically infected by the Epstein-Barr virus (EBV). It is well established that EBV is associated with a number of malignancies, and advances in knowledge of EBV-related malignancies are being made every year. Several studies have analysed the global epidemiology and geographic distribution of EBV-related cancers. However, most have only described a single cancer type or subtype in isolation or limited their study to the three or four most common EBV-related cancers. This review will present an overview on the spectrum of cancers linked to EBV based on observations of associations and proportions in the published literature while also using these observations to estimate the incidence and mortality burden of some of these cancers. METHOD: We have reviewed the literature on defining features, distribution and outcomes across six cancers with a relatively large EBV-related case burden: Nasopharyngeal carcinoma (NPC), Gastric carcinoma (GC), Hodgkin lymphoma (HL), Burkitt lymphoma (BL), Diffuse large B-cell lymphoma (DLBCL) and Extranodal NK/T-cell lymphoma, Nasal type (ENKTL-NT). We retrieved published region-specific EBV-related case proportions for NPC, GC, HL and BL and performed meta-analyses on pooled region-specific studies of EBV-related case proportions for DLBCL and ENKTL-NT. We match these pooled proportions with their respective regional incidence and mortality numbers retrieved from a publicly available cancer database. Additionally, we also reviewed the literature on several other less common EBV-related cancers to summarize their key characteristics herein. CONCLUSION: We estimated that EBV-related cases from these six cancers accounted for 239,700-357,900 new cases and 137,900-208,700 deaths in 2020. This review highlights the significant global impact of EBV-related cancers and extends the spectrum of disease that could benefit from an EBV-specific therapeutic.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Herpesvirus Humano 4 / Infecciones por Virus de Epstein-Barr / Neoplasias Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: J Cancer Res Clin Oncol Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Herpesvirus Humano 4 / Infecciones por Virus de Epstein-Barr / Neoplasias Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: J Cancer Res Clin Oncol Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Alemania