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Lipidome changes in alcohol-related brain damage.
Smith, Caine C; Sheedy, Donna L; McEwen, Holly P; Don, Anthony S; Kril, Jillian J; Sutherland, Greg T.
Afiliación
  • Smith CC; Faculty of Medicine and Health, School of Medical Sciences and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Sheedy DL; Faculty of Medicine and Health, School of Medical Sciences and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • McEwen HP; Centenery Institute, The University of Sydney, Sydney, New South Wales, Australia.
  • Don AS; Faculty of Medicine and Health, School of Medical Sciences and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
  • Kril JJ; Centenery Institute, The University of Sydney, Sydney, New South Wales, Australia.
  • Sutherland GT; Faculty of Medicine and Health, School of Medical Sciences and Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia.
J Neurochem ; 160(2): 271-282, 2022 01.
Article en En | MEDLINE | ID: mdl-34699608
Alcohol-related brain injury is characterized by cognitive deficits and brain atrophy with the prefrontal cortex particularly susceptible. White matter in the human brain is lipid rich and a major target of damage from chronic alcohol abuse; yet, there is sparse information on how these lipids are affected. Here, we used untargeted lipidomics as a discovery tool to describe these changes in the prefrontal, middle temporal, and visual cortices of human subjects with alcohol use disorder and controls. Significant changes to the lipidome, predominantly in the prefrontal and visual cortices, and differences between the white and grey matter of each brain region were identified. These effects include broad decreases to phospholipids and ceramide, decreased polyunsaturated fatty acids, decreased sphingadiene backbones, and selective decreases in cholesteryl ester fatty acid chains. Our findings show that chronic alcohol abuse results in selective changes to the neurolipidome, which likely reflects both the directs effects on the brain and concurrent effects on the liver.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Química Encefálica / Alcoholismo / Lipidómica Tipo de estudio: Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurochem Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Química Encefálica / Alcoholismo / Lipidómica Tipo de estudio: Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Neurochem Año: 2022 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido