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Fracture Risk and Its Prevention Patterns in Korean Patients with Polymyalgia Rheumatica: a Retrospective Cohort Study.
Nam, Bora; Sung, Yoon-Kyoung; Choi, Chan-Bum; Kim, Tae-Hwan; Jun, Jae-Bum; Bae, Sang-Cheol; Yoo, Dae-Hyun; Cho, Soo-Kyung.
Afiliación
  • Nam B; Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
  • Sung YK; Hanyang University Institute for Rheumatology Research, Seoul, Korea.
  • Choi CB; Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
  • Kim TH; Hanyang University Institute for Rheumatology Research, Seoul, Korea.
  • Jun JB; Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
  • Bae SC; Hanyang University Institute for Rheumatology Research, Seoul, Korea.
  • Yoo DH; Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
  • Cho SK; Hanyang University Institute for Rheumatology Research, Seoul, Korea.
J Korean Med Sci ; 36(41): e263, 2021 Oct 25.
Article en En | MEDLINE | ID: mdl-34697929
BACKGROUND: To evaluate the incidence of fractures and fracture risk factors in Korean patients with polymyalgia rheumatica (PMR). METHODS: All PMR patients who visited a rheumatology clinic at a tertiary referral hospital between March 2005 and March 2018 were retrospectively assessed. We estimated bone mineral density (BMD) screening rate within 6 months of the first visit and classified the patients according to the performance and results of BMD screening. Incidence rates (IRs) of fractures were calculated in each group and risk factors for fractures were identified using Poisson regression analysis. RESULTS: A total of 95 PMR patients with median (interquartile range) age of 64.0 (56.0-72.0) years were included. Baseline BMD was assessed in only 55.8% of these patients (n = 53); 24 patients with osteoporosis, 20 with osteopenia, and 9 with normal BMD. During 433.1 person-years (PYs) of observation, 17 fractures occurred in 12 patients (IR, 3.93 [95% confidence interval (CI), 2.46-6.26]/100 PYs); 8.32 (95% CI, 4.09-16.90)/100 PYs in the osteopenia group, 3.40 (95% CI, 1.30-8.90)/100 PYs in the osteoporosis group, and 3.37 (95% CI, 1.53-7.39)/100 PYs in the no BMD test group. Risk factors for fractures were female sex, advanced age (≥ 65 years), longer follow-up duration, initial glucocorticoid dose ≥ 10 mg/day, and higher cumulative glucocorticoid dose over the first 6 months. CONCLUSION: The incidence rate of fractures in Korean patients with PMR was 3.93/100 PYs. Female sex, advanced age, longer follow-up duration, and increased glucocorticoid dose are risk factors for osteoporotic fracture.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimialgia Reumática / Fracturas Óseas Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Korean Med Sci Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article Pais de publicación: Corea del Sur
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimialgia Reumática / Fracturas Óseas Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Korean Med Sci Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article Pais de publicación: Corea del Sur