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Mechanisms of nitric oxide generation in living systems.
Burov, Oleg N; Kletskii, Mikhail E; Kurbatov, Sergey V; Lisovin, Anton V; Fedik, Nikita S.
Afiliación
  • Burov ON; Department of Chemistry, Southern Federal University, 7, Zorge St., Rostov-on-Don, 344090, Russia. Electronic address: bboleg@gmail.com.
  • Kletskii ME; Department of Chemistry, Southern Federal University, 7, Zorge St., Rostov-on-Don, 344090, Russia.
  • Kurbatov SV; Department of Chemistry, Southern Federal University, 7, Zorge St., Rostov-on-Don, 344090, Russia.
  • Lisovin AV; Department of Chemistry, Southern Federal University, 7, Zorge St., Rostov-on-Don, 344090, Russia.
  • Fedik NS; Department of Chemistry, Southern Federal University, 7, Zorge St., Rostov-on-Don, 344090, Russia.
Nitric Oxide ; 118: 1-16, 2022 01 01.
Article en En | MEDLINE | ID: mdl-34688861
In modern chemical and biochemical studies, special attention is paid to molecular systems capable of generating nitric oxide (NO), which is one of the most important signalling molecules in the body and can trigger a whole cascade of reactions. Despite the importance of this molecule, the mechanisms of its formation in living organisms remain a subject of debate. This review combines the most important methods of releasing NO from endogenous and exogenous sources. The history of endogenous NO donors dates back more than 150 years, since the synthesis of nitroglycerin, which remains the standard vasodilator today, even though it is known that it and many other similar compounds lead to the development of a nitrate tolerance. Particular awareness is devoted to the mechanisms of NO formation without the participation of enzymes, since these methods are most important for creating exogenous sources of NO as drugs. The study of NO formation methods is centred on both the creation of new NO donors and understanding the mechanisms of tolerance to them.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxido Nítrico Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Nitric Oxide Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxido Nítrico Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Nitric Oxide Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos