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Anti-aging and anti-oxidant activities of murine short interspersed nuclear element antisense RNA.
Song, Zhixue; Shah, Suleman; Lv, Baixue; Ji, Ning; Liu, Xin; Yan, Lifang; Khan, Murad; Zhao, Yufang; Wu, Peiyuan; Liu, Shufeng; Zheng, Long; Su, Libo; Wang, Xiufang; Lv, Zhanjun.
Afiliación
  • Song Z; Department of Genetics, Hebei Medical University, Hebei Key Lab of Laboratory Animal, Shijiazhuang, 050017, Hebei Province, PR China. Electronic address: 18701394@hebmu.edu.cn.
  • Shah S; Department of Genetics, Hebei Medical University, Hebei Key Lab of Laboratory Animal, Shijiazhuang, 050017, Hebei Province, PR China. Electronic address: 72019010@stu.hebmu.edu.cn.
  • Lv B; Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, PR China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, 430022, Hubei Province, PR China. Electronic address: snowlv0318@126.com.
  • Ji N; Department of Genetics, Hebei Medical University, Hebei Key Lab of Laboratory Animal, Shijiazhuang, 050017, Hebei Province, PR China. Electronic address: 15613380807@163.com.
  • Liu X; Department of Genetics, Hebei Medical University, Hebei Key Lab of Laboratory Animal, Shijiazhuang, 050017, Hebei Province, PR China. Electronic address: lx950114@163.com.
  • Yan L; Department of Genetics, Hebei Medical University, Hebei Key Lab of Laboratory Animal, Shijiazhuang, 050017, Hebei Province, PR China. Electronic address: lifangyiyaa@163.com.
  • Khan M; Department of Genetics, Hebei Medical University, Hebei Key Lab of Laboratory Animal, Shijiazhuang, 050017, Hebei Province, PR China. Electronic address: genetics6630@gmail.com.
  • Zhao Y; Department of Genetics, Hebei Medical University, Hebei Key Lab of Laboratory Animal, Shijiazhuang, 050017, Hebei Province, PR China. Electronic address: zhao_yufang@sina.com.
  • Wu P; Department of Genetics, Hebei Medical University, Hebei Key Lab of Laboratory Animal, Shijiazhuang, 050017, Hebei Province, PR China. Electronic address: wupeiyuanwu@163.com.
  • Liu S; Department of Genetics, Hebei Medical University, Hebei Key Lab of Laboratory Animal, Shijiazhuang, 050017, Hebei Province, PR China. Electronic address: liushf@126.com.
  • Zheng L; Department of Genetics, Hebei Medical University, Hebei Key Lab of Laboratory Animal, Shijiazhuang, 050017, Hebei Province, PR China. Electronic address: zhenglong-1022@163.com.
  • Su L; Department of Genetics, Hebei Medical University, Hebei Key Lab of Laboratory Animal, Shijiazhuang, 050017, Hebei Province, PR China. Electronic address: libo_su@yahoo.com.
  • Wang X; Department of Genetics, Hebei Medical University, Hebei Key Lab of Laboratory Animal, Shijiazhuang, 050017, Hebei Province, PR China. Electronic address: wangxf1966@hebmu.edu.cn.
  • Lv Z; Department of Genetics, Hebei Medical University, Hebei Key Lab of Laboratory Animal, Shijiazhuang, 050017, Hebei Province, PR China. Electronic address: lslab@hebmu.edu.cn.
Eur J Pharmacol ; 912: 174577, 2021 Dec 05.
Article en En | MEDLINE | ID: mdl-34688636
Short interspersed nuclear elements (SINEs) play a key role in regulating gene expression, and SINE RNAs are involved in age-related diseases. We investigated the anti-aging effects of a genetically engineered murine SINE B1 antisense RNA (B1as RNA) and explored its mechanism of action in naturally senescent BALB/c (≥14 months) and moderately senscent C57BL/6N (≥9 months) mice. After tail vein injection, B1as RNA was available in the blood of mice for approximately 30 min, persisted for approximately 2-4 h in most detected tissues and persisted approximately 48 h in lungs. We found that treatment with B1as RNA improved stamina and promoted hair re-growth in aged mice. Treatment with B1as RNA also partially rescued the increase in mitochondrial DNA copy number in liver and spleen tissues observed in aged and moderately senescent mice. Finally, treatment with B1as RNA increased the activities of superoxide dismutase and glutathione peroxidase in aged and moderately senescent mice, reduced these animals' malondialdehyde and reactive oxygen species levels, and modulated the expression of several aging-associated genes, including Sirtuin 1, p21, p16Ink4a, p15Ink4b and p19Arf, and anti-oxidant genes (Sesn1 and Sesn 2). These data suggest that B1as RNA inhibits the aging process by enhancing antioxidant activity, promoting the scavenging of free radicals, and modulating the expression of aging-associated genes. This is the first report describing the anti-aging activity of SINE antisense RNA, which may serve as an effective nucleic acid drug for the treatment of age-related diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / ARN sin Sentido / Elementos de Nucleótido Esparcido Corto / Antioxidantes Límite: Animals Idioma: En Revista: Eur J Pharmacol Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / ARN sin Sentido / Elementos de Nucleótido Esparcido Corto / Antioxidantes Límite: Animals Idioma: En Revista: Eur J Pharmacol Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos