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Pediatric reference intervals for 32 routine biochemical markers using the siemens healthineers atellica® CH assays in healthy children and adolescents.
Bohn, Mary Kathryn; Horn, Paul; League, Donna; Steele, Paul; Hall, Alexandra; Adeli, Khosrow.
Afiliación
  • Bohn MK; CALIPER Program, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
  • Horn P; Cincinnati Children's Hospital, Cincinnati, OH, United States.
  • League D; Siemens Healthcare Diagnostics Inc., Tarrytown, NY, United States.
  • Steele P; Cincinnati Children's Hospital, Cincinnati, OH, United States.
  • Hall A; CALIPER Program, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Canada.
  • Adeli K; CALIPER Program, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada. Electronic address: khosrow.adeli@sickkids.ca.
Clin Biochem ; 99: 69-77, 2022 Jan.
Article en En | MEDLINE | ID: mdl-34687749
BACKGROUND: Pediatric reference intervals are essential for test interpretation. With development of newer analytical systems, de novo reference interval establishment is of necessary importance. In the current study, pediatric reference intervals were determined for 32 analytes using Siemens Healthineers Atellica® CH assays in the CALIPER cohort of healthy children and adolescents. METHODS: Approximately 600 healthy children and adolescents were recruited with informed consent and collected serum samples were analyzed on the Siemens Healthineers Atellica® CH platform. Assays studied included enzymes, proteins, lipids, electrolytes, and additional markers Reference intervals were established according to Clinical and Laboratory Standards Institute (CLSI) guidelines. RESULTS: Of the 32 parameters, 26 required age partitioning and 18 required sex partitioning. Reference value distributions included consistent increases, decreases, and dynamic variation across the age continuum. Chloride, LDL cholesterol, glucose, lipase, sodium, and triglyceride demonstrated no age or sex-specific differences. CONCLUSION: The current study expands the clinical utility of the CALIPER database to include 32 Siemens Atellica® chemistry assays. Reference value distributions for Siemens assays mirrored those observed on other comparable assays/systems with few exceptions (e.g. lipase, direct and total bilirubin). These finding support the robustness of previously derived reference intervals in the CALIPER cohort and other global cohorts.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Análisis Químico de la Sangre / Bases de Datos Factuales / Caracteres Sexuales Tipo de estudio: Guideline Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Clin Biochem Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Análisis Químico de la Sangre / Bases de Datos Factuales / Caracteres Sexuales Tipo de estudio: Guideline Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Clin Biochem Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos