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Perfusion MRI using endogenous deoxyhemoglobin as a contrast agent: Preliminary data.
Poublanc, Julien; Sobczyk, Olivia; Shafi, Reema; Sayin, Ece Su; Schulman, Jacob; Duffin, James; Uludag, Kamil; Wood, John C; Vu, Chau; Dharmakumar, Rohan; Fisher, Joseph A; Mikulis, David J.
Afiliación
  • Poublanc J; Joint Department of Medical Imaging and the Functional Neuroimaging Lab, University Health Network, Toronto, Ontario, Canada.
  • Sobczyk O; Joint Department of Medical Imaging and the Functional Neuroimaging Lab, University Health Network, Toronto, Ontario, Canada.
  • Shafi R; Department of Anaesthesia and Pain Management, University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Sayin ES; Joint Department of Medical Imaging and the Functional Neuroimaging Lab, University Health Network, Toronto, Ontario, Canada.
  • Schulman J; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
  • Duffin J; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
  • Uludag K; Techna Institute, University Health Network, Toronto, Ontario, Canada.
  • Wood JC; Department of Anaesthesia and Pain Management, University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Vu C; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
  • Dharmakumar R; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
  • Fisher JA; Techna Institute & Koerner Scientist in MR Imaging, University Health Network, Toronto, Ontario, Canada.
  • Mikulis DJ; Center for Neuroscience Imaging Research, Institute for Basic Science & Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Magn Reson Med ; 86(6): 3012-3021, 2021 12.
Article en En | MEDLINE | ID: mdl-34687064
PURPOSE: To demonstrate the feasibility of mapping cerebral perfusion metrics with BOLD MRI during modulation of pulmonary venous oxygen saturation. METHODS: A gas blender with a sequential gas delivery breathing circuit was used to implement rapid isocapnic changes in the partial pressure of oxygen of the arterial blood. Partial pressure of oxygen was initially lowered to a baseline of 40 mmHg. It was then rapidly raised to 95 mmHg for 20 s before rapidly returning to baseline. The induced cerebral changes in deoxyhemoglobin concentration were tracked over time using BOLD MRI in 6 healthy subjects and 1 patient with cerebral steno-occlusive disease. BOLD signal change, contrast-to-noise ratio, and time delay metrics were calculated. Perfusion metrics such as mean transit time, relative cerebral blood volume, and relative cerebral blood flow were calculated using a parametrized method with a mono-exponential residue function. An arterial input function from within the middle cerebral artery was used to scale relative cerebral blood volume and calculate absolute cerebral blood volume and cerebral blood flow. RESULTS: In normal subjects, average gray and white matter were: BOLD change = 6.3 ± 1.2% and 2.5 ± 0.6%, contrast-to-noise ratio = 4.3 ± 1.3 and 2.6 ± 0.7, time delay = 2.3 ± 0.6 s and 3.6 ± 0.7 s, mean transit time = 3.9 ± 0.6 s and 5.5 ± 0.6 s, relative cerebral blood volume = 3.7 ± 0.9 and 1.6 ± 0.4, relative cerebral blood flow = 70.1 ± 8.3 and 20.6 ± 4.0, cerebral blood flow volume = 4.1 ± 0.9 mL/100 g and 1.8 ± 0.5 mL/100 g, and cerebral blood flow = 97.2 ± 18.7 mL/100 g/min and 28.7 ± 5.9 mL/100 g/min. CONCLUSION: This study demonstrates that induced abrupt changes in deoxyhemoglobin can function as a noninvasive vascular contrast agent that may be used for cerebral perfusion imaging.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Circulación Cerebrovascular / Medios de Contraste Límite: Humans Idioma: En Revista: Magn Reson Med Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Circulación Cerebrovascular / Medios de Contraste Límite: Humans Idioma: En Revista: Magn Reson Med Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos