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Screening for Selective Anticancer Activity of 65 Extracts of Plants Collected in Western Andalusia, Spain.
Calderón-Montaño, José Manuel; Martínez-Sánchez, Sara María; Jiménez-González, Víctor; Burgos-Morón, Estefanía; Guillén-Mancina, Emilio; Jiménez-Alonso, Julio José; Díaz-Ortega, Patricia; García, Felipe; Aparicio, Abelardo; López-Lázaro, Miguel.
Afiliación
  • Calderón-Montaño JM; Department of Pharmacology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain.
  • Martínez-Sánchez SM; Department of Vegetal Biology and Ecology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain.
  • Jiménez-González V; Department of Food Technology and Nutrition, San Antonio Catholic University, 30107 Murcia, Spain.
  • Burgos-Morón E; Department of Pharmacology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain.
  • Guillén-Mancina E; Department of Pharmacology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain.
  • Jiménez-Alonso JJ; Department of Pharmacology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain.
  • Díaz-Ortega P; Department of Pharmacology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain.
  • García F; Department of Pharmacology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain.
  • Aparicio A; Department of Vegetal Biology and Ecology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain.
  • López-Lázaro M; Department of Vegetal Biology and Ecology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain.
Plants (Basel) ; 10(10)2021 Oct 15.
Article en En | MEDLINE | ID: mdl-34686002
Finding cytotoxic drugs with a high selectivity towards cancer cells is crucial to improve the low survival rates of patients diagnosed with metastatic cancers. Since plants are an important source of anticancer drugs, we have screened 65 extracts from 45 plants collected in several areas of Western Andalusia (Spain) for cytotoxic activity on lung cancer cells versus lung normal cells. An extract from the leaves of Tetraclinis articulata (Vahl) Mast. (Cupressaceae) showed a marked cytotoxicity (IC50 = 0.37 ± 0.03 µg/mL) and selectivity (selectivity index = 378.3) against the lung cancer cells; cisplatin, 5-fluorouracil, and an extract from the leaves of Taxus baccata L. (Taxaceae) were less cytotoxic and selective. Extracts from Cascabela thevetia (L.) Lippold (Apocynaceae), Frangula alnus Mill. (Rhamnaceae), Iberis ciliata subsp. contracta (Pers.) Moreno (Brassicaceae), Juniperus macrocarpa Sm (Cupressaceae), and Pancratium maritimum L. (Amaryllidaceae) also showed selective cytotoxicity (selectivity index > 10). Active extracts were also tested against a panel of cancer cell lines from a variety tissues. The plants identified in this work are potential sources of natural compounds with selective toxicity towards cancer cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Idioma: En Revista: Plants (Basel) Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Idioma: En Revista: Plants (Basel) Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza