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Facile Synthesis of 3-Substituted Thiazolo[2,3-α]tetrahydroisoquinolines.
Huang, Sheng-Han; Huang, Wan-Yu; Zhang, Guo-Lun; Yang, Te-Fang.
Afiliación
  • Huang SH; Department of Applied Chemistry, National Chi Nan University, Puli, Nantou 545, Taiwan.
  • Huang WY; Department of Applied Chemistry, National Chi Nan University, Puli, Nantou 545, Taiwan.
  • Zhang GL; Department of Applied Chemistry, National Chi Nan University, Puli, Nantou 545, Taiwan.
  • Yang TF; Department of Applied Chemistry, National Chi Nan University, Puli, Nantou 545, Taiwan.
Molecules ; 26(20)2021 Oct 11.
Article en En | MEDLINE | ID: mdl-34684705
It was found that 4-hydroxy-2-butenoic ester (11) could not react with 3,4-dihydro-isoquinoline (4a). Individual addition reactions of γ-mercapto-α,ß-unsaturated esters (18) and -unsaturated amide (19) with 3,4-dihydroisoquinolines (4) were carried out under appropriate conditions to provide the corresponding thiazolo[2,3-α]isoquinoline derivatives with good yields (up to 87%) and significant diastereomeric selectivity. The mechanism of the crucial reaction was discussed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza