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Oat Extract Avenanthramide-C Reverses Hippocampal Long-Term Potentiation Decline in Tg2576 Mice.
Lee, Yu-Young; Wang, Ming; Son, Yurim; Yang, Eun-Ju; Kang, Moon-Seok; Kim, Hyun-Joo; Kim, Hyung-Seok; Jo, Jihoon.
Afiliación
  • Lee YY; Department of Central Area, National Institute of Crop Science, Rural Development Administration, Suwon 16429, Korea.
  • Wang M; Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju 501-757, Korea.
  • Son Y; Department of Central Area, National Institute of Crop Science, Rural Development Administration, Suwon 16429, Korea.
  • Yang EJ; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, 80 Daehak-ro, Daegu 41566, Korea.
  • Kang MS; Department of Central Area, National Institute of Crop Science, Rural Development Administration, Suwon 16429, Korea.
  • Kim HJ; Department of Central Area, National Institute of Crop Science, Rural Development Administration, Suwon 16429, Korea.
  • Kim HS; Department of Forensic Medicine, Chonnam National University Medical School, Gwangju 501-757, Korea.
  • Jo J; Center for Creative Biomedical Scientists, Chonnam National University Medical School, Gwangju 501-757, Korea.
Molecules ; 26(20)2021 Oct 10.
Article en En | MEDLINE | ID: mdl-34684684
Memory deterioration in Alzheimer's disease (AD) is thought to be underpinned by aberrant amyloid ß (Aß) accumulation, which contributes to synaptic plasticity impairment. Avenanthramide-C (Avn-C), a polyphenol compound found predominantly in oats, has a range of biological properties. Herein, we performed methanolic extraction of the Avns-rich fraction (Fr. 2) from germinated oats using column chromatography, and examined the effects of Avn-C on synaptic correlates of memory in a mouse model of AD. Avn-C was identified in Fr. 2 based on 1H-NMR analysis. Electrophysiological recordings were performed to examine the effects of Avn-C on the hippocampal long-term potentiation (LTP) in a Tg2576 mouse model of AD. Avn-C from germinated oats restored impaired LTP in Tg2576 mouse hippocampal slices. Furthermore, Avn-C-facilitated LTP was associated with changes in the protein levels of phospho-glycogen synthase kinase-3ß (p-GSK3ß-S9) and cleaved caspase 3, which are involved in Aß-induced synaptic impairment. Our findings suggest that the Avn-C extract from germinated oats may be beneficial for AD-related synaptic plasticity impairment and memory decline.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Potenciación a Largo Plazo / Enfermedad de Alzheimer / Ortoaminobenzoatos / Hipocampo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Potenciación a Largo Plazo / Enfermedad de Alzheimer / Ortoaminobenzoatos / Hipocampo Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Suiza