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LncRNAs in the Regulation of Genes and Signaling Pathways through miRNA-Mediated and Other Mechanisms in Clear Cell Renal Cell Carcinoma.
Braga, Eleonora A; Fridman, Marina V; Filippova, Elena A; Loginov, Vitaly I; Pronina, Irina V; Burdennyy, Alexey M; Karpukhin, Alexander V; Dmitriev, Alexey A; Morozov, Sergey G.
Afiliación
  • Braga EA; Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia.
  • Fridman MV; Vavilov Institute of General Genetics, Russian Academy of Sciences, 119991 Moscow, Russia.
  • Filippova EA; Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia.
  • Loginov VI; Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia.
  • Pronina IV; Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia.
  • Burdennyy AM; Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia.
  • Karpukhin AV; Research Centre for Medical Genetics, 115522 Moscow, Russia.
  • Dmitriev AA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
  • Morozov SG; Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia.
Int J Mol Sci ; 22(20)2021 Oct 17.
Article en En | MEDLINE | ID: mdl-34681854
The fundamental novelty in the pathogenesis of renal cell carcinoma (RCC) was discovered as a result of the recent identification of the role of long non-coding RNAs (lncRNAs). Here, we discuss several mechanisms for the dysregulation of the expression of protein-coding genes initiated by lncRNAs in the most common and aggressive type of kidney cancer-clear cell RCC (ccRCC). A model of competitive endogenous RNA (ceRNA) is considered, in which lncRNA acts on genes through the lncRNA/miRNA/mRNA axis. For the most studied oncogenic lncRNAs, such as HOTAIR, MALAT1, and TUG1, several regulatory axes were identified in ccRCC, demonstrating a number of sites for various miRNAs. Interestingly, the LINC00973/miR-7109/Siglec-15 axis represents a novel agent that can suppress the immune response in patients with ccRCC, serving as a valuable target in addition to the PD1/PD-L1 pathway. Other mechanisms of action of lncRNAs in ccRCC, involving direct binding with proteins, mRNAs, and genes/DNA, are also considered. Our review briefly highlights methods by which various mechanisms of action of lncRNAs were verified. We pay special attention to protein targets and signaling pathways with which lncRNAs are associated in ccRCC. Thus, these new data on the different mechanisms of lncRNA functioning provide a novel basis for understanding the pathogenesis of ccRCC and the identification of new prognostic markers and targets for therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Transducción de Señal / Regulación Neoplásica de la Expresión Génica / ARN Largo no Codificante / Neoplasias Renales Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Transducción de Señal / Regulación Neoplásica de la Expresión Génica / ARN Largo no Codificante / Neoplasias Renales Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza