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Identification of a choroid plexus vascular barrier closing during intestinal inflammation.
Carloni, Sara; Bertocchi, Alice; Mancinelli, Sara; Bellini, Martina; Erreni, Marco; Borreca, Antonella; Braga, Daniele; Giugliano, Silvia; Mozzarelli, Alessandro M; Manganaro, Daria; Fernandez Perez, Daniel; Colombo, Federico; Di Sabatino, Antonio; Pasini, Diego; Penna, Giuseppe; Matteoli, Michela; Lodato, Simona; Rescigno, Maria.
Afiliación
  • Carloni S; Humanitas University, Department of Biomedical Sciences, 20072 Pieve Emanuele (Milan), Italy.
  • Bertocchi A; IRCCS Humanitas Research Hospital, 20089 Rozzano, Milan, Italy.
  • Mancinelli S; IRCCS Humanitas Research Hospital, 20089 Rozzano, Milan, Italy.
  • Bellini M; Humanitas University, Department of Biomedical Sciences, 20072 Pieve Emanuele (Milan), Italy.
  • Erreni M; IRCCS Humanitas Research Hospital, 20089 Rozzano, Milan, Italy.
  • Borreca A; Humanitas University, Department of Biomedical Sciences, 20072 Pieve Emanuele (Milan), Italy.
  • Braga D; IRCCS Humanitas Research Hospital, 20089 Rozzano, Milan, Italy.
  • Giugliano S; Humanitas University, Department of Biomedical Sciences, 20072 Pieve Emanuele (Milan), Italy.
  • Mozzarelli AM; IRCCS Humanitas Research Hospital, 20089 Rozzano, Milan, Italy.
  • Manganaro D; IRCCS Humanitas Research Hospital, 20089 Rozzano, Milan, Italy.
  • Fernandez Perez D; Institute of Neuroscience, National Research Council, c/o Humanitas Research Hospital, 20089 Rozzano, Milan, Italy.
  • Colombo F; IRCCS Humanitas Research Hospital, 20089 Rozzano, Milan, Italy.
  • Di Sabatino A; IRCCS Humanitas Research Hospital, 20089 Rozzano, Milan, Italy.
  • Pasini D; Humanitas University, Department of Biomedical Sciences, 20072 Pieve Emanuele (Milan), Italy.
  • Penna G; IRCCS Humanitas Research Hospital, 20089 Rozzano, Milan, Italy.
  • Matteoli M; Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, 20139 Milan, Italy.
  • Lodato S; Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, 20139 Milan, Italy.
  • Rescigno M; IRCCS Humanitas Research Hospital, 20089 Rozzano, Milan, Italy.
Science ; 374(6566): 439-448, 2021 Oct 22.
Article en En | MEDLINE | ID: mdl-34672740
Up to 40% of patients with inflammatory bowel disease present with psychosocial disturbances. We previously identified a gut vascular barrier that controls the dissemination of bacteria from the intestine to the liver. Here, we describe a vascular barrier in the brain choroid plexus (PVB) that is modulated in response to intestinal inflammation through bacteria-derived lipopolysaccharide. The inflammatory response induces PVB closure after gut vascular barrier opening by the up-regulation of the wingless-type, catenin-beta 1 (Wnt/ß-catenin) signaling pathway, rendering it inaccessible to large molecules. In a model of genetically driven closure of choroid plexus endothelial cells, we observed a deficit in short-term memory and anxiety-like behavior, suggesting that PVB closure may correlate with mental deficits. Inflammatory bowel disease­related mental symptoms may thus be the consequence of a deregulated gut­brain vascular axis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Plexo Coroideo / Intestinos / Trastornos de la Memoria / Memoria a Corto Plazo Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Science Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colitis Ulcerosa / Plexo Coroideo / Intestinos / Trastornos de la Memoria / Memoria a Corto Plazo Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Science Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos