Your browser doesn't support javascript.
loading
KIF13B-mediated VEGFR2 trafficking is essential for vascular leakage and metastasis in vivo.
Waters, Stephen B; Dominguez, Joseph R; Cho, Hyun-Dong; Sarich, Nicolene A; Malik, Asrar B; Yamada, Kaori H.
Afiliación
  • Waters SB; Department of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL, USA.
  • Dominguez JR; Department of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL, USA.
  • Cho HD; Department of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL, USA.
  • Sarich NA; Department of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL, USA.
  • Malik AB; Department of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL, USA.
  • Yamada KH; Department of Pharmacology and Regenerative Medicine, University of Illinois College of Medicine, Chicago, IL, USA horiguch@uic.edu.
Life Sci Alliance ; 5(1)2022 01.
Article en En | MEDLINE | ID: mdl-34670814
VEGF-A induces vascular leakage and angiogenesis via activating the cell surface localized receptor VEGF receptor 2 (VEGFR2). The amount of available VEGFR2 at the cell surface is however tightly regulated by trafficking of VEGFR2 by kinesin family 13 B (KIF13B), a plus-end kinesin motor, to the plasma membrane of endothelial cells (ECs). Competitive inhibition of interaction between VEGFR2 and KIF13B by a peptide kinesin-derived angiogenesis inhibitor (KAI) prevented pathological angiogenesis in models of cancer and eye disease associated with defective angiogenesis. Here, we show the protective effects of KAI in VEGF-A-induced vascular leakage and cancer metastasis. Using an EC-specific KIF13B knockout (Kif13b iECKO ) mouse model, we demonstrated the function of EC expressed KIF13B in mediating VEGF-A-induced vascular leakage, angiogenesis, tumor growth, and cancer metastasis. Thus, KIF13B-mediated trafficking of VEGFR2 to the endothelial surface has an essential role in pathological angiogenesis induced by VEGF-A, and is therefore a potential therapeutic target.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Permeabilidad Capilar / Cinesinas / Receptor 2 de Factores de Crecimiento Endotelial Vascular / Proteínas de la Membrana / Metástasis de la Neoplasia Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Life Sci Alliance Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Permeabilidad Capilar / Cinesinas / Receptor 2 de Factores de Crecimiento Endotelial Vascular / Proteínas de la Membrana / Metástasis de la Neoplasia Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Life Sci Alliance Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos