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Scleral growth stunting via sub-Tenon injection of cross-linking solutions in live rabbits.
Hoang, Quan V; Wen, Quan; Paik, David C; Chun, Yong Yao; Silverman, Ronald; Nagasaki, Takayuki; Trokel, Stephen L; Zyablitskaya, Mariya.
Afiliación
  • Hoang QV; Singapore Eye Research Institute, Singapore National Eye Centre at Duke-NUS Medical School, Singapore mariya.zyablitskaya@gmail.com donny.hoang@singhealth.com.sg.
  • Wen Q; Ophthalmology, Columbia University, New York, New York, USA.
  • Paik DC; Ophthalmology, Columbia University, New York, New York, USA.
  • Chun YY; Ophthalmology, Columbia University, New York, New York, USA.
  • Silverman R; Singapore Eye Research Institute, Singapore National Eye Centre at Duke-NUS Medical School, Singapore.
  • Nagasaki T; School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore.
  • Trokel SL; Ophthalmology, Columbia University, New York, New York, USA.
  • Zyablitskaya M; Ophthalmology, Columbia University, New York, New York, USA.
Br J Ophthalmol ; 107(6): 889-894, 2023 06.
Article en En | MEDLINE | ID: mdl-34670748
BACKGROUND: Scleral cross-linking is a potential method to inhibit axial elongation of the eye, preventing the progression of pathological myopia. Formaldehyde releasers, which are common preservatives found in cosmetics and ophthalmic solutions, have been shown to be not only effective in cross-linking corneal collagen in vitro and in vivo, but also have minimal toxicity effects on the eye. The present study aims to evaluate the efficacy of scleral cross-linking using sodium hydroxymethylglycinate (SMG) to inhibit eye growth using an in vivo rabbit model. METHODS: A cross-linking solution containing 40 mM SMG was delivered to the sub-Tenon's space behind the equator. The application regimen included a two-quadrant injection performed five times over 2 weeks on New Zealand White rabbits (n=5, group 1), and one-time injection followed for up to 5 days on Dutch-Belted rabbits (n=6, group 2). Group 1 was monitored serially for axial length changes using B-scan ultrasound for 5-6 weeks. Group 2 was injected with a higher viscosity solution formulation. Both groups were evaluated for thermal denaturation temperature changes of the sclera postmortem. RESULTS: Axial growth was limited by 10%-20% following SMG treatment as compared with the untreated eye. Thermal denaturation analysis showed increased heat resistance of the treated eyes in the areas of injection. Overall, the SMG treatment inhibited eye growth with few side effects from the injections. CONCLUSIONS: Cross-linking solutions delivered via sub-Tenon injection provide a potential method for limiting axial length growth in progressive myopia and could be used as a potential treatment for myopia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerótica / Miopía Degenerativa Límite: Animals Idioma: En Revista: Br J Ophthalmol Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerótica / Miopía Degenerativa Límite: Animals Idioma: En Revista: Br J Ophthalmol Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido