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PD-L1 (Programmed Death Ligand 1) Regulates T-Cell Differentiation to Control Adaptive Venous Remodeling.
Matsubara (松原 裕), Yutaka; Gonzalez, Luis; Kiwan, Gathe; Liu (刘 佳), Jia; Langford, John; Gao (高 明杰), Mingjie; Gao (高 喜翔), Xixiang; Taniguchi (谷口 良輔), Ryosuke; Yatsula, Bogdan; Furuyama (古山 正), Tadashi; Matsumoto (松本 拓也), Takuya; Komori (古森 公浩), Kimihiro; Mori (森 正樹), Masaki; Dardik, Alan.
Afiliación
  • Matsubara (松原 裕) Y; Vascular Biology and Therapeutics Program (Y.M., L.G., G.K., J. Liu, J. Langford, M.G., X.G., R.T., B.Y., A.D.).
  • Gonzalez L; Department of Surgery and Sciences, Kyushu University, Fukuoka, Japan (Y.M., T.F., M.M.).
  • Kiwan G; Vascular Biology and Therapeutics Program (Y.M., L.G., G.K., J. Liu, J. Langford, M.G., X.G., R.T., B.Y., A.D.).
  • Liu (刘 ä½³) J; Vascular Biology and Therapeutics Program (Y.M., L.G., G.K., J. Liu, J. Langford, M.G., X.G., R.T., B.Y., A.D.).
  • Langford J; Vascular Biology and Therapeutics Program (Y.M., L.G., G.K., J. Liu, J. Langford, M.G., X.G., R.T., B.Y., A.D.).
  • Gao (高 明杰) M; Vascular Biology and Therapeutics Program (Y.M., L.G., G.K., J. Liu, J. Langford, M.G., X.G., R.T., B.Y., A.D.).
  • Gao (高 喜翔) X; Vascular Biology and Therapeutics Program (Y.M., L.G., G.K., J. Liu, J. Langford, M.G., X.G., R.T., B.Y., A.D.).
  • Taniguchi (谷口 良輔) R; Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, Beijing, China (M.G.).
  • Yatsula B; Vascular Biology and Therapeutics Program (Y.M., L.G., G.K., J. Liu, J. Langford, M.G., X.G., R.T., B.Y., A.D.).
  • Furuyama (古山 æ­£) T; Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China (X.G).
  • Matsumoto (松本 拓也) T; Vascular Biology and Therapeutics Program (Y.M., L.G., G.K., J. Liu, J. Langford, M.G., X.G., R.T., B.Y., A.D.).
  • Komori (古森 公浩) K; Division of Vascular Surgery, The University of Tokyo, Japan (R.T.).
  • Mori (森 正樹) M; Vascular Biology and Therapeutics Program (Y.M., L.G., G.K., J. Liu, J. Langford, M.G., X.G., R.T., B.Y., A.D.).
  • Dardik A; Department of Surgery and Sciences, Kyushu University, Fukuoka, Japan (Y.M., T.F., M.M.).
Arterioscler Thromb Vasc Biol ; 41(12): 2909-2922, 2021 12.
Article en En | MEDLINE | ID: mdl-34670406
OBJECTIVE: Patients with end-stage renal disease depend on hemodialysis for survival. Although arteriovenous fistulae (AVF) are the preferred vascular access for hemodialysis, the primary success rate of AVF is only 30% to 50% within 6 months, showing an urgent need for improvement. PD-L1 (programmed death ligand 1) is a ligand that regulates T-cell activity. Since T cells have an important role during AVF maturation, we hypothesized that PD-L1 regulates T cells to control venous remodeling that occurs during AVF maturation. Approach and results: In the mouse aortocaval fistula model, anti-PD-L1 antibody (200 mg, 3×/wk intraperitoneal) was given to inhibit PD-L1 activity during AVF maturation. Inhibition of PD-L1 increased T-helper type 1 cells and T-helper type 2 cells but reduced regulatory T cells to increase M1-type macrophages and reduce M2-type macrophages; these changes were associated with reduced vascular wall thickening and reduced AVF patency. Inhibition of PD-L1 also inhibited smooth muscle cell proliferation and increased endothelial dysfunction. The effects of anti-PD-L1 antibody on adaptive venous remodeling were diminished in nude mice; however, they were restored after T-cell transfer into nude mice, indicating the effects of anti-PD-L1 antibody on venous remodeling were dependent on T cells. CONCLUSIONS: Regulation of PD-L1 activity may be a potential therapeutic target for clinical translation to improve AVF maturation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T / Diferenciación Celular / Antígeno B7-H1 / Remodelación Vascular Límite: Animals Idioma: En Revista: Arterioscler Thromb Vasc Biol Asunto de la revista: ANGIOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T / Diferenciación Celular / Antígeno B7-H1 / Remodelación Vascular Límite: Animals Idioma: En Revista: Arterioscler Thromb Vasc Biol Asunto de la revista: ANGIOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos