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Overall survival is improved with total thyroidectomy and radiation for male patients and patients older than 55 with T2N0M0 Stage 1 classic papillary thyroid cancer.
MacKinney, Erin C; Kuchta, Kristine M; Winchester, David J; Khokar, Amna M; Holoubek, Simon A; Moo-Young, Tricia A; Prinz, Richard A.
Afiliación
  • MacKinney EC; Department of Surgery, NorthShore University HealthSystem, Evanston, IL; Department of Surgery, University of Chicago, Chicago, IL.
  • Kuchta KM; Bioinformatics and Research Core, NorthShore University HealthSystem, Evanston, IL.
  • Winchester DJ; Department of Surgery, NorthShore University HealthSystem, Evanston, IL; Department of Surgery, University of Chicago, Chicago, IL.
  • Khokar AM; Department of Surgery, University of Chicago, Chicago, IL.
  • Holoubek SA; Augusta University, Otolaryngology Department, Head and Neck Surgery, Augusta, GA.
  • Moo-Young TA; Department of Surgery, NorthShore University HealthSystem, Evanston, IL; Department of Surgery, University of Chicago, Chicago, IL.
  • Prinz RA; Department of Surgery, NorthShore University HealthSystem, Evanston, IL; Department of Surgery, University of Chicago, Chicago, IL. Electronic address: rprinz@northshore.org.
Surgery ; 171(1): 197-202, 2022 01.
Article en En | MEDLINE | ID: mdl-34666913
BACKGROUND: We examine whether surgery extent and radiation administration affect overall survival for cT2N0M0 classic papillary thyroid cancer according to age and sex. METHODS: Patients with cT2N0M0 classic papillary thyroid cancer tumors in the National Cancer Data Base (2004-2016) were selected. Multivariable Cox regression analysis compared patients (combined male + female cohorts) having lobectomy to those having total thyroidectomy with or without radiation (primarily radioactive iodine) for ages: 18 to 45, 46 to 55, and >55 years. In addition, 1:1 propensity score matching and Kaplan-Meier curves with 10-year overall survival estimates, and log-rank test were stratified by age and sex. RESULTS: Lobectomy had equivalent overall survival to total thyroidectomy without and with radiation for patients (combined male + female cohorts) aged 18 to 45 and 46 to 55 years on multivariable analysis. On propensity score matching there was overall survival advantage for total thyroidectomy with radiation over both lobectomy and total thyroidectomy for men (ages 18-90+ combined) and overall survival advantage in patients (combined male + female cohort) aged >55 years having total thyroidectomy with radiation versus lobectomy. On propensity score matching there were no overall survival differences in women (ages 18-90+ combined) or patients (combined male + female cohort) aged 18 to 45 and 46 to 55 years having either lobectomy, total thyroidectomy, or total thyroidectomy with radiation. CONCLUSION: For cT2N0M0 classic papillary thyroid cancer, total thyroidectomy with radiation improves 10-year overall survival for patients (combined male + female cohort) aged >55 years and men (ages 18-90+ combined).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiroidectomía / Neoplasias de la Tiroides / Cáncer Papilar Tiroideo / Radioisótopos de Yodo Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Surgery Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiroidectomía / Neoplasias de la Tiroides / Cáncer Papilar Tiroideo / Radioisótopos de Yodo Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Surgery Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos