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Population-based cohort study of the efficacy of brentuximab vedotin in relapsed systemic anaplastic large-cell lymphoma using Public Health England data.
Halligan, Sarah J; Grainge, Matthew J; Martinez-Calle, Nicolas; Fox, Christopher P; Bishton, Mark J.
Afiliación
  • Halligan SJ; Nottingham University Hospitals NHS Trust, Nottingham, UK.
  • Grainge MJ; Population and Lifespan Sciences, School of Medicine, University of Nottingham, Nottingham, UK.
  • Martinez-Calle N; Department of Clinical Haematology, Nottingham University Hospitals NHS Trust, Nottingham, UK.
  • Fox CP; Department of Clinical Haematology, Nottingham University Hospitals NHS Trust, Nottingham, UK.
  • Bishton MJ; Department of Clinical Haematology, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Br J Haematol ; 196(4): 932-938, 2022 02.
Article en En | MEDLINE | ID: mdl-34664265
Systemic anaplastic large-cell lymphoma (sALCL) is a rare T-cell lymphoma associated with poor prognosis after relapse. The immunoconjugate brentuximab vedotin (BV) first became available for relapsed sALCL in England in 2013, following the results of a pivotal phase II study. We present a population-based study describing outcomes of relapsed sALCL in England after BV, using Public Health England data. We obtained information on all relapsed/refractory (r/r) sALCL patients ≥18 years treated with BV monotherapy in England between 1 January 2014 and 31 December 2019. The final cohort comprised 127 patients with a median age of 60 years (range 19-89). Eighteen (14·2%) had received stem cell transplant in first remission. Median two-year overall survival (OS) was 46·6%. The vast majority of deaths (59) occurred within 18 months, with very few events after this. Receipt of BV as second line compared to third or fourth line was associated with significantly improved survival (two-year OS 50·3% vs 29·7%, P = 0·03). There was no difference in OS for different subgroups, including anaplastic lymphoma kinase status, age, gender, or receipt of stem cell transplantation in first response. We report excellent survival following treatment with BV in a real-world setting, comparable with previous clinical trial data.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma Anaplásico de Células Grandes / Antineoplásicos Inmunológicos / Brentuximab Vedotina Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Br J Haematol Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma Anaplásico de Células Grandes / Antineoplásicos Inmunológicos / Brentuximab Vedotina Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Br J Haematol Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido