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Evaluation by different mechanisms of the protective effects of vitamin B12 on methotrexate nephrotoxicity.
Ozturk, E; Karabulut, D; Akin, A T; Kaymak, E; Kuloglu, N; Yakan, B.
Afiliación
  • Ozturk E; Faculty of Medicine, Histology-Embriology Department, Harran University, Sanliurfa, Turkey. emelozturk@harran.edu.tr.
  • Karabulut D; Faculty of Medicine, Histology-Embriology Department, Erciyes University, Kayseri, Turkey.
  • Akin AT; Faculty of Science, Biology Department, Erciyes University, Kayseri, Turkey.
  • Kaymak E; Faculty of Medicine, Histology-Embriology Department, Bozok University, Yozgat, Turkey.
  • Kuloglu N; Faculty of Medicine, Histology-Embriology Department, Erciyes University, Kayseri, Turkey.
  • Yakan B; Faculty of Medicine, Histology-Embriology Department, Erciyes University, Kayseri, Turkey.
J Mol Histol ; 53(1): 133-143, 2022 Feb.
Article en En | MEDLINE | ID: mdl-34655350
Methotrexate is used for cure of many cancer types. It has many side effects. For this reason, obtaining a nephroprotective agent is obligatory. In the study, our aim is to determine probable effects of Vitamin B12 on MTX caused kidney damages in rats. Rats were randomly divided into 4 groups, including 8 animals in each group. Control group, VitB12 group (3 µg-kg-ip B12 throughout 15 days), MTX group (at the 8th day of experiment, a single dose of 20 mg-kg-ip MTX), Vit B12 + MTX group (3 µg-kg-ip B12 throughout 15 days and at the 8th day of experiment, a single dose of 20 mg-kg-ip MTX) Animals were anesthetized and kidney tissues were removed to evaluate biochemically, immunohistochemically and histopathologycally. There were histopathological deteriorations, rises of apoptotic cells, expressions of heat shock proteins, endoplasmic reticulum stress and inflammation markers in the MTX group. In the MTX group, Superoxide Dismutase (SOD), Total Antioxidant Status (TAS) and Catalase (CAT) levels decreased, but Total Oxidant Status TOS, Malondialdehyde (MDA) and interleukin-6 (IL6) levels increased. In addition, there was amelioration in kidney tissue in Vit B12 + MTX group compared to the MTX group. We suggest that Vit B12 can be used to reduce the toxic effects of MTX.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina B 12 / Complejo Vitamínico B / Metotrexato / Enfermedades Renales / Antimetabolitos Antineoplásicos Límite: Animals Idioma: En Revista: J Mol Histol Asunto de la revista: HISTOCITOQUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina B 12 / Complejo Vitamínico B / Metotrexato / Enfermedades Renales / Antimetabolitos Antineoplásicos Límite: Animals Idioma: En Revista: J Mol Histol Asunto de la revista: HISTOCITOQUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Países Bajos