A modified source-detector configuration for the discrimination between normal and diseased human breast based on the continuous-wave diffuse optical imaging approach: a simulation study.

Mahdy, Shimaa; Hamdy, Omnia; Hassan, Mohammed A; Eldosoky, Mohamed A A

Mahdy, Shimaa; Hamdy, Omnia; Hassan, Mohammed A; Eldosoky, Mohamed A A.

Afiliación

Mahdy S; Department of Biomedical Engineering, Faculty of Engineering, Helwan University, Cairo, Egypt.
Hamdy O; Department of Electrical Engineering, Egyptian Academy for Engineering and Advanced Technology (EAE&AT) Affiliated to Ministry of Military Production, Cairo, Egypt.
Hassan MA; Department of Engineering Applications of Lasers, National Institute of Laser Enhanced Sciences, Cairo University, Giza, Egypt. omnia@niles.edu.eg.
Eldosoky MAA; Department of Biomedical Engineering, Faculty of Engineering, Helwan University, Cairo, Egypt.

Lasers Med Sci ; 37(3): 1855-1864, 2022 Apr.

Article en En | MEDLINE | ID: mdl-34651256

RESUMEN

Breast tumors are among the most common types of tumors that can affect both genders. It may spread to the whole breast without any symptoms. Therefore, the early detection and accurate diagnosis of breast tumors are significantly important. Current approaches for breast cancer screening such as positron emission tomography (PET) and magnetic resonance imaging (MRI) have some limitations of being time and money-consuming. In addition, mammography screening is not recommended for women under forty. Consequently, optical techniques have been introduced as safe and functional alternatives. Diffuse optical imaging is a non-invasive imaging technique that utilizes near-infrared light to examine biological tissues based on measuring the optical transmission and/or reflection at various locations on the tissue surface. In this paper, we propose a modified arrangement between the laser source and the detectors for distinguishing tumors from normal breast tissue. A three-dimensional model of the normal human breast with three types of tumors is developed using a COMSOL simulation software based on the finite element solution of Helmholtz equation to estimate optical fluence distribution. The breast model consists of four layers: skin, fat, glandular, and muscle, where the tumor is included in the glandular layer. Different wavelengths were used to determine the most proper wavelength for the discrimination between the normal tissue and tumor. The obtained results were verified using the receiver operating characteristic (ROC) method. The resultant fluence images show different features between normal breast and breast with tumor especially using 600-nm incident laser as demonstrated by the obtained ROC curves.

Asunto(s)

Neoplasias de la Mama; Mama; Mama/diagnóstico por imagen; Mama/patología; Neoplasias de la Mama/diagnóstico por imagen; Neoplasias de la Mama/patología; Femenino; Humanos; Masculino; Mamografía; Imagen Óptica; Tomografía de Emisión de Positrones

Palabras clave

Breast tumors; Diffusion equation; Finite element; Laser; Optical diagnosis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mama / Neoplasias de la Mama Tipo de estudio: Prognostic_studies / Screening_studies Límite: Female / Humans / Male Idioma: En Revista: Lasers Med Sci Asunto de la revista: BIOTECNOLOGIA / RADIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido

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