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Blocking of EGFR Signaling Is a Latent Strategy for the Improvement of Prognosis of HPV-Induced Cancer.
Qiu, Jianfa; Hu, Feifei; Shao, Tingting; Guo, Yuqiang; Dai, Zongmao; Nie, Huanhuan; Olasunkanmi, Oluwatayo Israel; Qi, Yue; Chen, Yang; Lin, Lexun; Zhao, Wenran; Zhong, Zhaohua; Wang, Yan.
Afiliación
  • Qiu J; Department of Microbiology, Harbin Medical University, Harbin, China.
  • Hu F; Department of Obstetrics, the First Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Shao T; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Guo Y; Department of Microbiology, Harbin Medical University, Harbin, China.
  • Dai Z; Department of Microbiology, Harbin Medical University, Harbin, China.
  • Nie H; Department of Microbiology, Harbin Medical University, Harbin, China.
  • Olasunkanmi OI; Department of Microbiology, Harbin Medical University, Harbin, China.
  • Qi Y; Department of Microbiology, Harbin Medical University, Harbin, China.
  • Chen Y; Department of Microbiology, Harbin Medical University, Harbin, China.
  • Lin L; Department of Microbiology, Harbin Medical University, Harbin, China.
  • Zhao W; Department of Cell Biology, Harbin Medical University, Harbin, China.
  • Zhong Z; Department of Microbiology, Harbin Medical University, Harbin, China.
  • Wang Y; Department of Microbiology, Harbin Medical University, Harbin, China.
Front Oncol ; 11: 633794, 2021.
Article en En | MEDLINE | ID: mdl-34646755
Human papillomavirus (HPV) is a double-stranded DNA (dsDNA) virus, and its high-risk subtypes increase cancer risks. However, the mechanism of HPV infection and pathogenesis still remain unclear. Therefore, understanding the molecular mechanisms and the pathogenesis of HPV are crucial in the prevention of HPV-related cancers. In this study, we analyzed cervix squamous cell carcinoma (CESC) and head and neck carcinoma (HNSC) combined data to investigate various HPV-induced cancer common features. We showed that epidermal growth factor receptor (EGFR) was downregulated in HPV-positive (HPV+) cancer, and that HPV+ cancer patients exhibited better prognosis than HPV-negative (HPV-) cancer patients. Our study also showed that TP53 mutation rate is lower in HPV+ cancer than in HPV- cancer and that TP53 can be modulated by HPV E7 protein. However, there was no significant difference in the expression of wildtype TP53 in both groups. Subsequently, we constructed HPV-human interaction network and found that EGFR is a critical factor. From the network, we also noticed that EGFR is regulated by HPV E7 protein and hsa-miR-944. Moreover, while phosphorylated EGFR is associated with a worse prognosis, EGFR total express level is not significantly correlated with prognosis. This indicates that EGFR activation will induce a worse outcome in HPV+ cancer patients. Further enrichment analysis showed that EGFR downstream pathway and cancer relative pathway are diversely activated in HPV+ cancer and HPV- cancer. In summary, HPV E7 protein downregulates EGFR that downregulates phosphorylated EGFR and inhibit EGFR-related pathways which in turn and consequently induce better prognosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Oncol Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Oncol Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza