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Hilar cholangiocarcinoma with extensive immunoglobulin G4 reaction.
Yamamura, Minako; Sato, Yasunori; Takahashi, Kenta; Nguyen Canh, Hiep; Li, Zihan; Kimoto, Tatsuya; Terasaki, Shuichi; Harada, Kenichi.
Afiliación
  • Yamamura M; Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Japan.
  • Sato Y; Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Japan.
  • Takahashi K; Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Japan.
  • Nguyen Canh H; Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Japan.
  • Li Z; Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Japan.
  • Kimoto T; Department of Radiology, Japan Red Cross Kanazawa Hospital Kanazawa, Japan.
  • Terasaki S; Department of Gastroenterology, Japan Red Cross Kanazawa Hospital Kanazawa, Japan.
  • Harada K; Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Japan.
Int J Clin Exp Pathol ; 14(9): 987-992, 2021.
Article en En | MEDLINE | ID: mdl-34646417
Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a systemic fibroinflammatory disorder that can involve multiple organs. It is often challenging to distinguish IgG4-related sclerosing cholangitis (IgG4-SC) from cholangiocarcinoma because of overlap in their clinical findings. A 75-year-old man presented to a hospital for a detailed examination of the elevation of some biliary enzymes. Radiographic examination revealed segmental bile duct with wall thickening of the common hepatic bile duct, and dilation of the peripheral branches. Transampullary biopsy showed a non-specific inflammatory reaction with several IgG4-positive cell infiltrations. There were no signs of malignancy. The liver biopsy showed bile duct injury accompanied by IgG4-positive cell infiltration. We then performed bile duct biopsy and finally diagnosed the patient with cholangiocarcinoma. We should remember that the IgG4 reaction is neither completely sensitive nor specific for IgG4-RD and avoid resting solely on the IgG4 reaction to precisely distinguish IgG4-SC from cholangiocarcinoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Clin Exp Pathol Asunto de la revista: PATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Clin Exp Pathol Asunto de la revista: PATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos