Inhibition of tumor progression and M2 microglial polarization by extracellular vesicle-mediated microRNA-124 in a 3D microfluidic glioblastoma microenvironment.

Hong, Soohyun; You, Jae Young; Paek, Kyurim; Park, Jubin; Kang, Su Jin; Han, Eun Hee; Choi, Nakwon; Chung, Seok; Rhee, Won Jong; Kim, Jeong Ah

Hong, Soohyun; You, Jae Young; Paek, Kyurim; Park, Jubin; Kang, Su Jin; Han, Eun Hee; Choi, Nakwon; Chung, Seok; Rhee, Won Jong; Kim, Jeong Ah.

Afiliación

Hong S; Research Center for Bioconvergence Analysis, Korea Basic Science Institute, Chungbuk 28119, Republic of Korea.
You JY; Center for Scientific Instrumentation, Korea Basic Science Institute, Chungbuk 28119, Republic of Korea.
Paek K; Program in Biomicro System Technology, Korea University, Seoul 02841, Republic of Korea.
Park J; Center for Scientific Instrumentation, Korea Basic Science Institute, Chungbuk 28119, Republic of Korea.
Kang SJ; Department of Bioengineering and Nano-Bioengineering, Incheon National University, Incheon 22012, Republic of Korea.
Han EH; Center for Scientific Instrumentation, Korea Basic Science Institute, Chungbuk 28119, Republic of Korea.
Choi N; Program in Biomicro System Technology, Korea University, Seoul 02841, Republic of Korea.
Chung S; Center for Scientific Instrumentation, Korea Basic Science Institute, Chungbuk 28119, Republic of Korea.
Rhee WJ; Program in Biomicro System Technology, Korea University, Seoul 02841, Republic of Korea.
Kim JA; Department of Bioengineering and Nano-Bioengineering, Incheon National University, Incheon 22012, Republic of Korea.

Theranostics ; 11(19): 9687-9704, 2021.

Article en En | MEDLINE | ID: mdl-34646393

Asunto(s)

Glioblastoma/genética; MicroARNs/genética; Microglía/metabolismo; Neoplasias Encefálicas/patología; Línea Celular Tumoral; Sistemas de Liberación de Medicamentos/métodos; Vesículas Extracelulares/genética; Vesículas Extracelulares/metabolismo; Glioblastoma/metabolismo; Células HEK293; Humanos; Activación de Macrófagos; Macrófagos/metabolismo; MicroARNs/metabolismo; Microfluídica; Microglía/fisiología; Microambiente Tumoral

Palabras clave

extracellular vesicle; glioblastoma; microRNA-124; microglia; three-dimensional (3D) cell culture

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microglía / Glioblastoma / MicroARNs Límite: Humans Idioma: En Revista: Theranostics Año: 2021 Tipo del documento: Article Pais de publicación: Australia

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