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Acute COVID-19 gene-expression profiles show multiple etiologies of long-term sequelae.
Thompson, Ryan C; Simons, Nicole W; Wilkins, Lillian; Cheng, Esther; Del Valle, Diane Marie; Hoffman, Gabriel E; Fennessy, Brian; Mouskas, Konstantinos; Francoeur, Nancy J; Johnson, Jessica S; Lepow, Lauren; Le Berichel, Jessica; Chang, Christie; Beckmann, Aviva G; Wang, Ying-Chih; Nie, Kai; Zaki, Nicholas; Tuballes, Kevin; Barcessat, Vanessa; Cedillo, Mario A; Huckins, Laura; Roussos, Panagiotis; Marron, Thomas U; Glicksberg, Benjamin S; Nadkarni, Girish; Gonzalez-Kozlova, Edgar; Kim-Schulze, Seunghee; Sebra, Robert; Merad, Miriam; Gnjatic, Sacha; Schadt, Eric E; Charney, Alexander W; Beckmann, Noam D.
Afiliación
  • Thompson RC; Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Simons NW; Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Wilkins L; Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Cheng E; Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Del Valle DM; Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Hoffman GE; Precision Immunology Institute, Mount Sinai, New York, NY 10029, USA.
  • Fennessy B; Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Mouskas K; Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Francoeur NJ; Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Johnson JS; The Susan and Leonard Feinstein Inflammatory Bowel Disease Clinical Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Lepow L; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Le Berichel J; Center for Advanced Genomics Technology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Chang C; Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Beckmann AG; Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Wang YC; Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Nie K; Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Zaki N; Precision Immunology Institute, Mount Sinai, New York, NY 10029, USA.
  • Tuballes K; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Barcessat V; Sema4, a Mount Sinai venture, Stamford CT, 06902, USA.
  • Cedillo MA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Huckins L; Center for Advanced Genomics Technology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Roussos P; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Marron TU; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Glicksberg BS; Precision Immunology Institute, Mount Sinai, New York, NY 10029, USA.
  • Nadkarni G; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Gonzalez-Kozlova E; Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Kim-Schulze S; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Sebra R; Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Merad M; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Gnjatic S; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Schadt EE; Mount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Charney AW; Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Beckmann ND; Precision Immunology Institute, Mount Sinai, New York, NY 10029, USA.
medRxiv ; 2021 Oct 05.
Article en En | MEDLINE | ID: mdl-34642700
Two years into the SARS-CoV-2 pandemic, the post-acute sequelae of infection are compounding the global health crisis. Often debilitating, these sequelae are clinically heterogeneous and of unknown molecular etiology. Here, a transcriptome-wide investigation of this new condition was performed in a large cohort of acutely infected patients followed clinically into the post-acute period. Gene expression signatures of post-acute sequelae were already present in whole blood during the acute phase of infection, with both innate and adaptive immune cells involved. Plasma cells stood out as driving at least two distinct clusters of sequelae, one largely dependent on circulating antibodies against the SARS-CoV-2 spike protein and the other antibody-independent. Altogether, multiple etiologies of post-acute sequelae were found concomitant with SARS-CoV-2 infection, directly linking the emergence of these sequelae with the host response to the virus.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies Idioma: En Revista: MedRxiv Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies Idioma: En Revista: MedRxiv Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos