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Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases.
Prakadan, Sanjay M; Alvarez-Breckenridge, Christopher A; Markson, Samuel C; Kim, Albert E; Klein, Robert H; Nayyar, Naema; Navia, Andrew W; Kuter, Benjamin M; Kolb, Kellie E; Bihun, Ivanna; Mora, Joana L; Bertalan, Mia Solana; Shaw, Brian; White, Michael; Kaplan, Alexander; Stocking, Jackson H; Wadsworth, Marc H; Lee, Eudocia Q; Chukwueke, Ugonma; Wang, Nancy; Subramanian, Megha; Rotem, Denisse; Cahill, Daniel P; Adalsteinsson, Viktor A; Miller, Jeffrey W; Sullivan, Ryan J; Carter, Scott L; Brastianos, Priscilla K; Shalek, Alex K.
Afiliación
  • Prakadan SM; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Alvarez-Breckenridge CA; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Markson SC; Broad Institute, Harvard University & Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Kim AE; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Klein RH; Ragon Institute, Harvard University, Massachusetts Institute of Technology, & Massachusetts General Hospital, Cambridge, MA, USA.
  • Nayyar N; Broad Institute, Harvard University & Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Navia AW; Department of Neurosurgery, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA.
  • Kuter BM; Broad Institute, Harvard University & Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Kolb KE; Division of Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Bihun I; Department of Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA.
  • Mora JL; Massachusetts General Hospital Cancer Center, Boston, MA, USA.
  • Bertalan MS; Broad Institute, Harvard University & Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Shaw B; Division of Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • White M; Department of Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA.
  • Kaplan A; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Stocking JH; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Wadsworth MH; Broad Institute, Harvard University & Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Lee EQ; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Chukwueke U; Ragon Institute, Harvard University, Massachusetts Institute of Technology, & Massachusetts General Hospital, Cambridge, MA, USA.
  • Wang N; Department of Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA.
  • Subramanian M; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Rotem D; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Cahill DP; Broad Institute, Harvard University & Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Adalsteinsson VA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Miller JW; Ragon Institute, Harvard University, Massachusetts Institute of Technology, & Massachusetts General Hospital, Cambridge, MA, USA.
  • Sullivan RJ; Department of Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA.
  • Carter SL; Department of Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA.
  • Brastianos PK; Department of Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA.
  • Shalek AK; Department of Medicine, Harvard Medical School & Massachusetts General Hospital, Boston, MA, USA.
Nat Commun ; 12(1): 5955, 2021 10 12.
Article en En | MEDLINE | ID: mdl-34642316
Asunto(s)
Neoplasias Encefálicas/tratamiento farmacológico; Antígeno CTLA-4/inmunología; Inhibidores de Puntos de Control Inmunológico/uso terapéutico; Carcinomatosis Meníngea/tratamiento farmacológico; Neoplasias Meníngeas/tratamiento farmacológico; Receptor de Muerte Celular Programada 1/inmunología; Microambiente Tumoral/efectos de los fármacos; Adulto; Anciano; Anticuerpos Monoclonales Humanizados/uso terapéutico; Neoplasias Encefálicas/inmunología; Neoplasias Encefálicas/mortalidad; Neoplasias Encefálicas/secundario; Linfocitos T CD8-positivos/efectos de los fármacos; Linfocitos T CD8-positivos/inmunología; Linfocitos T CD8-positivos/patología; Antígeno CTLA-4/antagonistas & inhibidores; Antígeno CTLA-4/genética; Ácidos Nucleicos Libres de Células/genética; Ácidos Nucleicos Libres de Células/inmunología; Femenino; Regulación Neoplásica de la Expresión Génica; Humanos; Inmunoterapia; Interferón gamma/genética; Interferón gamma/inmunología; Ipilimumab/uso terapéutico; Masculino; Carcinomatosis Meníngea/inmunología; Carcinomatosis Meníngea/mortalidad; Carcinomatosis Meníngea/patología; Neoplasias Meníngeas/inmunología; Neoplasias Meníngeas/mortalidad; Neoplasias Meníngeas/patología; Persona de Mediana Edad; Nivolumab/uso terapéutico; Receptor de Muerte Celular Programada 1/antagonistas & inhibidores; Receptor de Muerte Celular Programada 1/genética; Análisis de la Célula Individual; Análisis de Supervivencia; Microambiente Tumoral/genética; Microambiente Tumoral/inmunología
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Carcinomatosis Meníngea / Microambiente Tumoral / Antígeno CTLA-4 / Receptor de Muerte Celular Programada 1 / Inhibidores de Puntos de Control Inmunológico / Neoplasias Meníngeas Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Carcinomatosis Meníngea / Microambiente Tumoral / Antígeno CTLA-4 / Receptor de Muerte Celular Programada 1 / Inhibidores de Puntos de Control Inmunológico / Neoplasias Meníngeas Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido