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Cell-Based Regeneration and Treatment of Liver Diseases.
Hofmann, Julia; Hackl, Verena; Esser, Hannah; Meszaros, Andras T; Fodor, Margot; Öfner, Dietmar; Troppmair, Jakob; Schneeberger, Stefan; Hautz, Theresa.
Afiliación
  • Hofmann J; Department of Visceral, Transplant and Thoracic Surgery (VTT), Center of Operative Medicine, Daniel Swarovski Research Laboratory (DSL) and organLife Laboratory, Medical University of Innsbruck (MUI), 6020 Innsbruck, Austria.
  • Hackl V; Department of Visceral, Transplant and Thoracic Surgery (VTT), Center of Operative Medicine, Daniel Swarovski Research Laboratory (DSL) and organLife Laboratory, Medical University of Innsbruck (MUI), 6020 Innsbruck, Austria.
  • Esser H; Centre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, UK.
  • Meszaros AT; Department of Visceral, Transplant and Thoracic Surgery (VTT), Center of Operative Medicine, Daniel Swarovski Research Laboratory (DSL) and organLife Laboratory, Medical University of Innsbruck (MUI), 6020 Innsbruck, Austria.
  • Fodor M; Department of Visceral, Transplant and Thoracic Surgery (VTT), Center of Operative Medicine, Daniel Swarovski Research Laboratory (DSL) and organLife Laboratory, Medical University of Innsbruck (MUI), 6020 Innsbruck, Austria.
  • Öfner D; Department of Visceral, Transplant and Thoracic Surgery (VTT), Center of Operative Medicine, Daniel Swarovski Research Laboratory (DSL) and organLife Laboratory, Medical University of Innsbruck (MUI), 6020 Innsbruck, Austria.
  • Troppmair J; Department of Visceral, Transplant and Thoracic Surgery (VTT), Center of Operative Medicine, Daniel Swarovski Research Laboratory (DSL) and organLife Laboratory, Medical University of Innsbruck (MUI), 6020 Innsbruck, Austria.
  • Schneeberger S; Department of Visceral, Transplant and Thoracic Surgery (VTT), Center of Operative Medicine, Daniel Swarovski Research Laboratory (DSL) and organLife Laboratory, Medical University of Innsbruck (MUI), 6020 Innsbruck, Austria.
  • Hautz T; Department of Visceral, Transplant and Thoracic Surgery (VTT), Center of Operative Medicine, Daniel Swarovski Research Laboratory (DSL) and organLife Laboratory, Medical University of Innsbruck (MUI), 6020 Innsbruck, Austria.
Int J Mol Sci ; 22(19)2021 Sep 24.
Article en En | MEDLINE | ID: mdl-34638617
The liver, in combination with a functional biliary system, is responsible for maintaining a great number of vital body functions. However, acute and chronic liver diseases may lead to irreversible liver damage and, ultimately, liver failure. At the moment, the best curative option for patients suffering from end-stage liver disease is liver transplantation. However, the number of donor livers required by far surpasses the supply, leading to a significant organ shortage. Cellular therapies play an increasing role in the restoration of organ function and can be integrated into organ transplantation protocols. Different types and sources of stem cells are considered for this purpose, but highly specific immune cells are also the focus of attention when developing individualized therapies. In-depth knowledge of the underlying mechanisms governing cell differentiation and engraftment is crucial for clinical implementation. Additionally, novel technologies such as ex vivo machine perfusion and recent developments in tissue engineering may hold promising potential for the implementation of cell-based therapies to restore proper organ function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tratamiento Basado en Trasplante de Células y Tejidos / Hepatopatías Tipo de estudio: Guideline Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tratamiento Basado en Trasplante de Células y Tejidos / Hepatopatías Tipo de estudio: Guideline Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Suiza