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Relationship between Circulating Lipids and Cytokines in Metastatic Castration-Resistant Prostate Cancer.
Lin, Hui-Ming; Yeung, Nicole; Hastings, Jordan F; Croucher, David R; Huynh, Kevin; Meikle, Thomas G; Mellett, Natalie A; Kwan, Edmond M; Davis, Ian D; Tran, Ben; Mahon, Kate L; Zhang, Alison; Stockler, Martin R; Briscoe, Karen; Marx, Gavin; Bastick, Patricia; Crumbaker, Megan L; Joshua, Anthony M; Azad, Arun A; Meikle, Peter J; Horvath, Lisa G.
Afiliación
  • Lin HM; Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
  • Yeung N; St Vincent's Clinical School, UNSW Sydney (the University of New South Wales), Darlinghurst, NSW 2010, Australia.
  • Hastings JF; The Kinghorn Cancer Centre, St Vincent's Hospital, Darlinghurst, NSW 2010, Australia.
  • Croucher DR; Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
  • Huynh K; The Kinghorn Cancer Centre, St Vincent's Hospital, Darlinghurst, NSW 2010, Australia.
  • Meikle TG; Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
  • Mellett NA; St Vincent's Clinical School, UNSW Sydney (the University of New South Wales), Darlinghurst, NSW 2010, Australia.
  • Kwan EM; The Kinghorn Cancer Centre, St Vincent's Hospital, Darlinghurst, NSW 2010, Australia.
  • Davis ID; Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
  • Tran B; St Vincent's Clinical School, UNSW Sydney (the University of New South Wales), Darlinghurst, NSW 2010, Australia.
  • Mahon KL; The Kinghorn Cancer Centre, St Vincent's Hospital, Darlinghurst, NSW 2010, Australia.
  • Zhang A; Metabolomics Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.
  • Stockler MR; Metabolomics Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.
  • Briscoe K; Metabolomics Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.
  • Marx G; Department of Medical Oncology, Monash Health, Clayton, VIC 3168, Australia.
  • Bastick P; Department of Medicine, School of Clinical Sciences, Monash University, Clayton, VIC 3168, Australia.
  • Crumbaker ML; Eastern Health Clinical School, Monash University, Box Hill, VIC 3128, Australia.
  • Joshua AM; Cancer Services, Eastern Health, Box Hill, VIC 3128, Australia.
  • Azad AA; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3010, Australia.
  • Meikle PJ; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
  • Horvath LG; Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
Cancers (Basel) ; 13(19)2021 Oct 01.
Article en En | MEDLINE | ID: mdl-34638448
Circulating lipids or cytokines are associated with prognosis in metastatic castration-resistant prostate cancer (mCRPC). This study aimed to understand the interactions between lipid metabolism and immune response in mCRPC by investigating the relationship between the plasma lipidome and cytokines. Plasma samples from two independent cohorts of men with mCRPC (n = 146, 139) having life-prolonging treatments were subjected to lipidomic and cytokine profiling (290, 763 lipids; 40 cytokines). Higher baseline levels of sphingolipids, including ceramides, were consistently associated with shorter overall survival in both cohorts, whereas the associations of cytokines with overall survival were inconsistent. Increasing levels of IL6, IL8, CXCL16, MPIF1, and YKL40 correlated with increasing levels of ceramide in both cohorts. Men with a poor prognostic 3-lipid signature at baseline had a shorter time to radiographic progression (poorer treatment response) if their lipid profile at progression was similar to that at baseline, or their cytokine profile at progression differed to that at baseline. In conclusion, baseline levels of circulating lipids were more consistent as prognostic biomarkers than cytokines. The correlation between circulating ceramides and cytokines suggests the regulation of immune responses by ceramides. The association of treatment response with the change in lipid profiles warrants further research into metabolic interventions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza