FBXL2 counteracts Grp94 to destabilize EGFR and inhibit EGFR-driven NSCLC growth.

Niu, Mengmeng; Xu, Jing; Liu, Yang; Li, Yuhuang; He, Tao; Ding, Liangping; He, Yajun; Yi, Yong; Li, Fengtian; Guo, Rongtian; Gao, Ya; Li, Rui; Li, Luping; Fu, Mengyuan; Hu, Qingyong; Luo, Yangkun; Zhang, Chunyan; Qin, Kewei; Yi, Jianqiao; Yu, Shuhan; Yang, Jian; Chen, Hu; Wang, Liang; Li, Zhonghan; Dong, Biao; Qi, Shiqian; Ouyang, Liang; Zhang, Yujun; Cao, Yang; Xiao, Zhi-Xiong Jim

Niu, Mengmeng; Xu, Jing; Liu, Yang; Li, Yuhuang; He, Tao; Ding, Liangping; He, Yajun; Yi, Yong; Li, Fengtian; Guo, Rongtian; Gao, Ya; Li, Rui; Li, Luping; Fu, Mengyuan; Hu, Qingyong; Luo, Yangkun; Zhang, Chunyan; Qin, Kewei; Yi, Jianqiao; Yu, Shuhan; Yang, Jian; Chen, Hu; Wang, Liang; Li, Zhonghan; Dong, Biao; Qi, Shiqian; Ouyang, Liang; Zhang, Yujun; Cao, Yang; Xiao, Zhi-Xiong Jim.

Afiliación

Niu M; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Xu J; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Liu Y; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Li Y; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
He T; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Ding L; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
He Y; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Yi Y; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Li F; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Guo R; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Gao Y; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Li R; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Li L; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Fu M; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Hu Q; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Luo Y; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Zhang C; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Qin K; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Yi J; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Yu S; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Yang J; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Chen H; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Wang L; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Li Z; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Dong B; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Qi S; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Ouyang L; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Zhang Y; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Cao Y; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China. cao@scu.edu.cn.
Xiao ZJ; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China. jimzx@scu.edu.cn.

Nat Commun ; 12(1): 5919, 2021 10 11.

Article en En | MEDLINE | ID: mdl-34635651

Asunto(s)

Carcinoma de Pulmón de Células no Pequeñas/genética; Proteínas F-Box/genética; Neoplasias Pulmonares/genética; Glicoproteínas de Membrana/genética; Acrilamidas/farmacología; Compuestos de Anilina/farmacología; Animales; Antineoplásicos/farmacología; Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico; Carcinoma de Pulmón de Células no Pequeñas/mortalidad; Carcinoma de Pulmón de Células no Pequeñas/patología; Línea Celular Tumoral; Movimiento Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Resistencia a Antineoplásicos/efectos de los fármacos; Resistencia a Antineoplásicos/genética; Sinergismo Farmacológico; Receptores ErbB/genética; Receptores ErbB/metabolismo; Proteínas F-Box/metabolismo; Regulación Neoplásica de la Expresión Génica; Humanos; Neoplasias Pulmonares/tratamiento farmacológico; Neoplasias Pulmonares/mortalidad; Neoplasias Pulmonares/patología; Glicoproteínas de Membrana/metabolismo; Ratones; Ratones Desnudos; Nebivolol/farmacología; Inhibidores de Proteínas Quinasas/farmacología; Transducción de Señal; Análisis de Supervivencia; Carga Tumoral/efectos de los fármacos; Ensayos Antitumor por Modelo de Xenoinjerto

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glicoproteínas de Membrana / Carcinoma de Pulmón de Células no Pequeñas / Proteínas F-Box / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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