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Fiber-specific white matter analysis reflects upper motor neuron impairment in amyotrophic lateral sclerosis.
Ogura, Aya; Kawabata, Kazuya; Watanabe, Hirohisa; Choy, Shao Wei; Bagarinao, Epifanio; Kato, Toshiyasu; Imai, Kazunori; Masuda, Michihito; Ohdake, Reiko; Hara, Kazuhiro; Nakamura, Ryoichi; Atsuta, Naoki; Nakamura, Tomohiko; Katsuno, Masahisa; Sobue, Gen.
Afiliación
  • Ogura A; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Kawabata K; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Watanabe H; Brain and Mind Research Center, Nagoya University, Nagoya, Japan.
  • Choy SW; Department of Neurology, School of Medicine, Fujita Health University, Toyoake, Japan.
  • Bagarinao E; Center for Intelligent Signal and Imaging Research, Universiti Teknologi PETRONAS, Seri Iskandar, Malaysia.
  • Kato T; Brain and Mind Research Center, Nagoya University, Nagoya, Japan.
  • Imai K; Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Masuda M; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Ohdake R; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Hara K; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Nakamura R; Brain and Mind Research Center, Nagoya University, Nagoya, Japan.
  • Atsuta N; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Nakamura T; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Katsuno M; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Sobue G; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Eur J Neurol ; 29(2): 432-440, 2022 02.
Article en En | MEDLINE | ID: mdl-34632672
BACKGROUND AND PURPOSE: To clarify the relationship between fiber-specific white matter changes in amyotrophic lateral sclerosis (ALS) and clinical signs of upper motor neuron (UMN) involvement, we performed a fixel-based analysis (FBA), a novel framework for diffusion-weighted imaging analysis. METHODS: We enrolled 96 participants, including 48 nonfamilial ALS patients and 48 age- and sex-matched healthy controls (HCs), in this study and conducted whole-brain FBA and voxel-based morphometry analysis. We compared the fiber density (FD), fiber morphology (fiber cross-section [FC]), and a combined index of FD and FC (FDC) between the ALS and HC groups. We performed a tract-of-interest analysis to extract FD values across the significant regions in the whole-brain analysis. Then, we evaluated the associations between FD values and clinical variables. RESULTS: The bilateral corticospinal tracts (CSTs) and the corpus callosum (CC) showed reduced FD and FDC in ALS patients compared with HCs (p < 0.05, familywise error-corrected), and the comparison of FCs revealed no region that was significantly different from another. Voxel-based morphometry showed cortical volume reduction in the regions, including the primary motor area. Clinical scores showed correlations with FD values in the CSTs (UMN score: rho = -0.530, p < 0.001; central motor conduction time [CMCT] in the upper limb: rho = -0.474, p = 0.008; disease duration: rho = -0.383, p = 0.007; ALS Functional Rating Scale-Revised: rho = 0.340, p = 0.018). In addition, patients whose CMCT was not calculated due to unevoked waves also showed FD reduction in the CSTs. CONCLUSIONS: Our findings suggest that FD values in the CST estimated via FBA can be potentially used in evaluating UMN impairments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sustancia Blanca / Esclerosis Amiotrófica Lateral Límite: Humans Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sustancia Blanca / Esclerosis Amiotrófica Lateral Límite: Humans Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido