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Xianling Gubao Capsule Prevents Cadmium-Induced Kidney Injury.
Huang, Jian; Ma, Xiao-Tong; Xu, Duo-Duo; Yao, Bao-Jin; Zhao, Da-Qing; Leng, Xiang-Yang; Liu, Jia.
Afiliación
  • Huang J; Department of Pharmaceutical Science, Changchun University of Chinese Medicine, Changchun, China.
  • Ma XT; Department of Pharmaceutical Science, Changchun University of Chinese Medicine, Changchun, China.
  • Xu DD; Department of Pharmaceutical Science, Changchun University of Chinese Medicine, Changchun, China.
  • Yao BJ; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin 130117, China.
  • Zhao DQ; Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin 130117, China.
  • Leng XY; The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin 130117, China.
  • Liu J; Department of Pharmaceutical Science, Changchun University of Chinese Medicine, Changchun, China.
Biomed Res Int ; 2021: 3931750, 2021.
Article en En | MEDLINE | ID: mdl-34621894
Xianling Gubao Capsule (XGC), a kind of capsule preparation of Chinese herbal officially approved for sale by the National Medical Products Administration (NMPA), has the effect of tonifying kidney and strengthening bones. Although the impact of XGC in treating bone diseases has been widely studied, the effect of XGC in kidney injury is unknown yet. The kidney injury model is established by intraperitoneal injection with cadmium chloride (CdCl2). Before model establishment, each XGC group was pregavaged with XGC for 10 d. After 10 d, CdCl2 was injected intraperitoneally into the model group and each XGC group, each XGC group continued to be gavaged with XGC for 4 weeks, and the control group was gavaged with equal doses of distilled water once daily. The level of serum urea nitrogen (BUN) and serum creatinine (Cr) is evaluated by kit. The effect of XGC on protecting kidney injury in mice with kidney injury is analyzed by histopathology (HE stain), immunohistochemistry (IHC), and real-time fluorescence quantitative PCR (RT-qPCR). The results show that CdCl2 significantly increases the level BUN and Cr in serum and results in remarkable pathological changes in the nephron, including tubule edema, congestion, and necrosis. While oral administration of XGC can significantly decrease BUN and Cr in serum and prevent and protect the kidney from the above injuries. In addition, the protein expression of p-mTOR was remarkably reduced, and the ratio of LC3II/LC3I protein and mRNA was significantly increased in mice with oral administration of XGC. Our findings suggest that XGC can prevent and protect kidney injury by improving the state of renal tubular hyperemia and necrosis and reduce the level of BUN and Cr in cadmium poisoning mice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadmio / Medicamentos Herbarios Chinos / Riñón Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Biomed Res Int Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadmio / Medicamentos Herbarios Chinos / Riñón Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Biomed Res Int Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos