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Lymphoepithelioma-like neoplasm of the biliary tract with 'probable low malignant potential'.
Khandakar, Binny; Liu, Jun-Ru; Thung, Swan; Li, Ying; Rhee, Hyungjin; Kagen, Alexander C; Sun-Wing Tong, Tommy; Nyun Park, Young; Theise, Neil; Oi-Lin Ng, Irene.
Afiliación
  • Khandakar B; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Liu JR; Department of Pathology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
  • Thung S; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Li Y; Department of Pathology, Mount Sinai Health System, New York, New York, USA.
  • Rhee H; Department of Radiology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
  • Kagen AC; Department of Radiology, Research Institute of Radiological Science,, Center for Clinical Imaging Data Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Sun-Wing Tong T; Department of Radiology, Icahn School of Medicine at Mount Sinai Hospital, New York, New York, USA.
  • Nyun Park Y; Department of Pathology, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
  • Theise N; Department of Pathology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Oi-Lin Ng I; Department of Pathology, New York University School of Medicine, New York City, New York, USA.
Histopathology ; 80(4): 720-728, 2022 Mar.
Article en En | MEDLINE | ID: mdl-34608670
AIMS: Lymphoepithelioma-like carcinomas (LELCs) are uncommon epithelial cancers characteristically showing two distinct components consisting of malignant epithelial cells and prominent dense lymphoid infiltrate. Hepatic LELCs consist of two types, the lymphoepithelioma-like hepatocellular carcinoma and lymphoepithelioma-like cholangiocarcinoma (LEL-CCA), with the latter being strongly associated with Epstein-Barr virus (EBV). METHODS AND RESULTS: We present a series of three cases of intrahepatic biliary EBV-associated LEL tumours in which the biliary epithelial component showed a distinctly benign appearance, instead of the usual malignant epithelial features of a typical CCA or EBV-associated LEL-CCA. In the lesions, the biliary epithelium showed interconnecting glands or cords of cells. All had a very low proliferation (Ki-67) index. Immunohistochemistry for IDH1 and TP53 performed on two cases was negative and molecular tests for EGFR and KRAS gene mutations performed on one were negative. Prognosis was very good in all three cases, with patients alive with no evidence of disease 24-62 months after surgery. Intriguingly, all three cases had co-infection of HBV and EBV. These cases are also discussed in the context of the 63 cases of LEL-CCA available in the literature, with a focus on epidemiology, clinicopathological features and potential research interests. CONCLUSIONS: Based on the distinct clinicopathological features and unique survival benefits, we believe these tumours represent the benign end of the spectrum of EBV-associated lymphoepithelial biliary carcinomas. Whether these tumours require a revision of the current nomenclature to 'lymphoepithelioma-like neoplasm of the biliary tract with probable low malignant potential' will require more detailed analysis with larger case-series.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Conductos Biliares / Carcinoma / Colangiocarcinoma / Carcinoma Hepatocelular / Infecciones por Virus de Epstein-Barr / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Histopathology Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de los Conductos Biliares / Carcinoma / Colangiocarcinoma / Carcinoma Hepatocelular / Infecciones por Virus de Epstein-Barr / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Female / Humans / Male Idioma: En Revista: Histopathology Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido